CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ.
1. Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm. 366, 840. 2. Holmes, W.F., et al. 2004. J. Cell. Physiol. 199, 317. 3. Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci. 10, 44.
Soluble in DMSO (>10 mg/ml), and ethanol (100 mM). Insoluble in water.
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Magnussen et alMagnussen et al. (PubMed ID 22446330) found that CD437 led to cell cycle arrest and induced apoptosis in the human metastatic melanoma cell lines FEMX-1 and WM239. -SCBT Publication Review
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