CD 437A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer

CD 437 (CAS 125316-60-1)

CD 437 | CAS 125316-60-1 is rated 5.0 out of 5 by 1.
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Synonym: AHPN; 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Application: A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer
CAS Number: 125316-60-1
Molecular Weight: 398.49
Molecular Formula: C27H26O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ.


References

1. Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm. 366, 840. 2. Holmes, W.F., et al. 2004. J. Cell. Physiol. 199, 317. 3. Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci. 10, 44.

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), and ethanol (100 mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
271.6-276° C
Boiling Point :
~595.0° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
OVCAR-3: IC50 = 0.13 µM (human); DU-145: IC50 = 0.28 µM (human); LNCaP: IC50 = 0.32 µM (human); ADMET: IC50 = 0.33 µM; IGROV-1: IC50 = 0.35 µM (human)
Ki Data :
RAR γ: Ki= 77 nM (human); RAR β: Ki= 2.48 µM (human); RAR α: Ki= 6.5 µM (human)
pK Values :
pKa: 4.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QJ1975900
PubChem CID :
135411
MDL Number :
MFCD03106506
SMILES :
C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Magnussen et al Magnussen et al. (PubMed ID 22446330) found that CD437 led to cell cycle arrest and induced apoptosis in the human metastatic melanoma cell lines FEMX-1 and WM239. -SCBT Publication Review
Date published: 2015-04-10
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