CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 (IC50: 6 nM). CCT128930 has been shown to exhibit marked antiproliferative activity against PTEN-deficient human tumor cell lines including U87MG human glioblastoma cells, LNCaP human prostate cancer cells and PC3 human prostate cancer cells (GI50's: U87MG = 6.3 μM, LNCaP = 0.35 μmol/L and PC3 = 1.9 μmol/L). Furthermore, CCT128930 causes a G1 arrest in PTEN-null U87MG human glioblastoma cells and Akt pathway blockade.
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CCT128930 Product Citations
See how others have used CCT128930. Click on the entry to view the PubMed entry
Do you have an Akt specific inhibitor that is not covered by a patent or that it will be soon generic?
Asked by: shoshi
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Wang FZ; et alWang FZ; et al. (PubMed ID: 24793486) determined that higher doses of CCT128930 increased apoptosis and activation of caspase-3, caspase-9, and PARP. -SCBT Publication Review
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