CCT128930A potent, ATP-competitive and selective inhibitor of Akt2

CCT128930 (CAS 885499-61-6)

CCT128930 | CAS 885499-61-6 is rated 5.0 out of 5 by 1.
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Synonym: 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine
Application: A potent, ATP-competitive and selective inhibitor of Akt2
CAS Number: 885499-61-6
Purity: ≥98%
Molecular Weight: 341.84
Molecular Formula: C18H20ClN5
* Refer to Certificate of Analysis for lot specific data (including water content).
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CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 (IC50: 6 nM). CCT128930 has been shown to exhibit marked antiproliferative activity against PTEN-deficient human tumor cell lines including U87MG human glioblastoma cells, LNCaP human prostate cancer cells and PC3 human prostate cancer cells (GI50's: U87MG = 6.3 μM, LNCaP = 0.35 μmol/L and PC3 = 1.9 μmol/L). Furthermore, CCT128930 causes a G1 arrest in PTEN-null U87MG human glioblastoma cells and Akt pathway blockade.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
17751819
SMILES :
C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4

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CCT128930  Product Citations

See how others have used CCT128930. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26122935  Kim, H. et al. 2015. Microvascular research. 101: 72-81.

PMID: # 24793486  Wang, F.Z. et al. 2014. Biochimie. 103: 118-25.

Citations 1 to 2 of 2 total

Do you have an Akt specific inhibitor that is not covered by a patent or that it will be soon generic? thank you shoshi

Asked by: shoshi
Thank you for your question. We offer quite a few chemicals that are Akt Inhibitors. You can find them on our website. https://www.scbt.com/scbt/browse/Chemicals-Protein-Interacting-Inhibitors-Activators-and-Substrates-Protein-Inhibitors/_/N-70w8k?Ntt=akt+inhibitor If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-06-27
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Rated 5 out of 5 by from Wang FZ; et al Wang FZ; et al. (PubMed ID: 24793486) determined that higher doses of CCT128930 increased apoptosis and activation of caspase-3, caspase-9, and PARP. -SCBT Publication Review
Date published: 2015-02-11
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