CBHA is a potent HDAC inhibitor and induces apoptosis in nine different neuroblastoma cell lines in culture. CBHA also completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/kg. Addition of retinoic acid increases efficacy of CBHA for suppressing tumor growth in mice.
1 Richon, V.M., Emiliani, S., Verdin, E., et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA 95 3003-3007 (1998). 2 Glick, R.D., Swendeman, S.L., Coffey, D.C., et al. Hybrid
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