CBHAA potent HDAC inhibitor

CBHA (CAS 174664-65-4)

CBHA | CAS 174664-65-4 is rated 5.0 out of 5 by 1.
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Synonym: Histone Deacetylase Inhibitor II; m-Carboxycinnamic Acid bis-Hydroxamide
Application: A potent HDAC inhibitor
CAS Number: 174664-65-4
Purity: ≥98%
Molecular Weight: 222.2
Molecular Formula: C10H10N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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CBHA is a potent HDAC inhibitor and induces apoptosis in nine different neuroblastoma cell lines in culture. CBHA also completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/kg. Addition of retinoic acid increases efficacy of CBHA for suppressing tumor growth in mice.


References

1 Richon, V.M., Emiliani, S., Verdin, E., et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA 95 3003-3007 (1998). 2 Glick, R.D., Swendeman, S.L., Coffey, D.C., et al. Hybrid

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5353484
SMILES :
C1=CC(=CC(=C1)C(=O)NO)/C=C/C(=O)NO

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CBHA  Product Citations

See how others have used CBHA. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22503103  de la Vega L, et al. 2012. Mol. Cell. 46(4): 472-83.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Chen et al Chen et al. (PubMed iD 24707477) found that CBHA blocked TNF- -activated MAPK/AP-1 signaling and PAI-1 expression in human pleural mesothelial cells (PMCs) via HDAC inhibition. -SCBT Publication Review
Date published: 2015-05-11
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