CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA) which exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor with Ki values of 210 and 30 nM, respectively. This compound behaves primarily as a CB1 receptor partial agonist and a CB2 receptor neutral antagonist in vitro.
1 Brizzi, A., Brizzi, V., Cascio, M.G., et al. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. J Med Chem 48 7343-7350 (2005). 2 Cascio, M.G., Bisogno, T., Palazzo, E., et al. In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands. Br J Pharmacol 149 431-440 (2006).
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