CB 13A potent CB1/CB2 receptor agonist with limited brain penetration

CB 13 (CAS 432047-72-8)

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Synonym: 1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone; CRA-13
Application: A potent CB1/CB2 receptor agonist with limited brain penetration
CAS Number: 432047-72-8
Purity: >98%
Molecular Weight: 368.47
Molecular Formula: C26H24O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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CB 13 is a potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (50 mM), and DMF (~20 mg/ml).
Storage :
Store at room temperature
Melting Point :
217.99° C (Predicted)
Boiling Point :
~559.8° C at 760 mmHg (Predicted)
Density :
1.13 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
CB1: EC5050 = 6.1 nM; CB1: IC50 = 15 nM (human); CB2: EC5050 = 27.9 nM; CB2: IC50 = 98 nM (human); CYP2C9: IC50 = 80.8 µM (human)
Ki Data :
CB2: Ki= 19 nM (human); CB1: Ki= 35 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9799417
MDL Number :
MFCD11519954
SMILES :
CCCCCOC1=CC=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43

Download SDS (MSDS)

Certificate of Analysis

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