Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, compound inhibits the growth of HCT-116 cells, making it less potent than nutlin-3 in the same assay. At concentrations at or below 1 µM, caylin-1 promotes the growth of HCT-116 cells approximately 20% compared to untreated cells.
1 Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).
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