CAY10589CAS: 1077626-52-8
MF: C25H28ClN3O2S
MW: 470.0
An inhibitor of 5-LO, Cox-1, and Cox-2.

CAY10589 (CAS 1077626-52-8)

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Synonym: 2-[[4-[([1,1-biphenyl]-4-ylmethyl)amino]-6-chloro-2-pyrimidinyl]thio]-octanoic acid
Application: An inhibitor of 5-LO, Cox-1, and Cox-2
CAS Number: 1077626-52-8
Molecular Weight: 470.0
Molecular Formula: C25H28ClN3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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CAY10589 is an inhibitor of mPGES-1 (IC50 = 1.3 μM), 5-LO (IC50 = 1.0 μM), and PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 exhibits minor inhibition of Cox-1 and Cox-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.


References

1 Koeberle, A., Zettl, H., Greiner, C., et al. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. J Med Chem 51 8068-8076 (2008).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25147690
SMILES :
CCCCCCC(C(=O)O)SC1=NC(=CC(=N1)Cl)NCC2=CC=C(C=C2)C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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