Catharanthine baseAn alkaloids present in Catharanthus roseus

Catharanthine base (CAS 2468-21-5)

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Application: An alkaloids present in Catharanthus roseus
CAS Number: 2468-21-5
Purity: ≥98%
Molecular Weight: 336.43
Molecular Formula: C21H24N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Catharanthine base is one of the many alkaloids present in Catharanthus roseus. Can be used as a starting material for the synthesis of the anti-tumor drugs vinblastine and vincristine. Catharanthine base is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.


References

1. Pennanen, S., et al. 1990. Photochem. Photobiol. 51: 515-518. PMID: 2367548
2. Prakash, V. and Timasheff, S.N. 1991. Biochemistry. 30: 873-880. PMID: 1988072
3. Uniyal, G.C., et al. 2001. Phytochem Anal. 12: 206-210. PMID: 11705028

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), water (< 1 mg/ml at 25° C), ethanol (3 mg/ml at 25° C), 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml), and DMF (~30 mg/ml).
Storage :
Store at 4° C
Melting Point :
126-128° C
Boiling Point :
491.51° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α20/D +34°±4°, c = 0.5 in CDCl3
IC50 :
Nicotinic receptor: IC50 = 59.6 µM
pK Values :
pKb: 7.1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NH6732500
Merck Index :
13: 1914
MDL Number :
MFCD01753356
EC Number :
219-586-6

Download SDS (MSDS)

Certificate of Analysis

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