caspase-8 Antibody (FLICE4-1-20) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
raised against full length caspase-8 of human origin
recommended for detection of caspase-8 of human origin by WB, IP and ELISA
See caspase-8 (8CSP03): sc-56070 for caspase-8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-8 Antibody (FLICE4-1-20) for WB applications. These reagents are now offered in bundles with caspase-8 Antibody (FLICE4-1-20) (see ordering information below).
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possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A and mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex (DISC), which activates caspase-8. The actived protein is released from the complex and further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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