Caspase-3 Inhibitor Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.

Caspase-3 Inhibitor (CAS 210344-95-9)

Caspase-3 Inhibitor | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
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Alternate Names: Z-DEVD-FMK
Application: Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥90% (solid)
Molecular Weight: 668.66
Molecular Formula: C30H41FN4O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


References

1. Schlegel, J. et al. 1996. J. Biol. Chem. 271(4): 1841-1844. PMID: 8567626
2. Nicholson, D.W. 1996. Nat. Biotechnol. 14(3): 297-301. PMID: 9630889
3. Masuda, Y. et al. 1997. Biochem. Biophys. Res. Commun. 234(3): 641-645. PMID: 9175767
4. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281(5381): 1312-1316. PMID: 9721091
5. Brockstedt, E., et al., 1998. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422
6. Henshall, D C., et al., 2000. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954
7. Kugawa, F., et al., 2000. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298
8. Nagarajah, N.S. et al. 2004. Mol. Cancer. 3(1): 38. PMID: 15613236
9. Cervantes, J. et al. 2008. Cell. Microbiol. 10(1): 41-52. PMID: 17662073

Usage :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Physical State :
Solid
Sequence :
Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK
Solubility :
Soluble in DMSO (13.37 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Caspase-3 Inhibitor (CAS 210344-95-9)  Product Citations

See how others have used Caspase-3 Inhibitor (CAS 210344-95-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 54 total

PMID: # 34975311  Gong, RH.|Yang, DJ.|Kwan, HY.|Lyu, AP.|Chen, GQ.|Bian, ZX.| et al. 2022. Int J Med Sci. 19: 175-185.

PMID: # 33618169  Wu, SW.|Su, CH.|Ho, YC.|Huang-Liu, R.|Tseng, CC.|Chiang, YW.|Yeh, KL.|Lee, SS.|Chen, WY.|Chen, CJ.|Li, YC.|Lee, CY.|Kuan, YH.| et al. 2021. Ecotoxicol Environ Saf. 213: 112062.

PMID: # 34607339  Zhang, ZH.|Yang, HX.|Jin, Q.|Wu, YL.|Cui, ZY.|Shang, Y.|Liu, J.|Zhan, ZY.|Lian, LH.|Nan, JX.| et al. 2021. Food Funct.

PMID: # 30904799  Zhao, W.|Li, H.|Hou, Y.|Jin, Y.|Zhang, L.| et al. 2019. World Neurosurg. 127: e346-e352.

PMID: # 31189945  Chambers, JS.|Brend, T.|Rabbitts, TH.| et al. 2019. Sci Rep. 9: 8553.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

PMID: # 30692621  Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

PMID: # 31035052  Huang, WC.|Gu, PY.|Fang, LW.|Huang, YL.|Lin, CF.|Liou, CJ.| et al. 2019. Phytomedicine. 61: 152852.

PMID: # 30161272  Chen, XB.|Li, W.|Chu, AX.| et al. 2019. J. Cell. Biochem. 120: 470-480.

PMID: # 31313541  Bishayee, K.|Habib, K.|Sadra, A.|Huh, SO.| et al. 2019. Cell. Physiol. Biochem. 53: 258-280.

Citations 1 to 10 of 54 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. The solubility of Caspase-3 Inhibitor, sc-3075, is DMSO/DMF (>=20 mM).
Answered by: Chemical Support 4
Date published: 2017-03-17
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Rated 5 out of 5 by from Nagarajah Nagarajah, NS. et al. (PubMed 15613236) used Caspase-3 Inhibitor (Z-DEVD-fmk) to create a caspase activity profile. Caspase-3 successfully inhibited activity of its target protease caspase-3, but not caspases 8 or 9. -SCBT Publication Review
Date published: 2015-04-29
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