Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Caspase-11 plays a crucial role in OLG death and pathogenesis in experimental autoimmune encephalomyelitis (EAE). Caspase-11 also leads to the synthesis of the functional form of the cytokine interleukin-1beta. Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. These ced-3 orthologs mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation of other pro-apoptotic molecules. Based on their substrate specificities and DNA sequence homologies, the 14 currently identified caspases may be divided into three groups: apoptotic initiators, apoptotic executioners and inflammatory mediators. Upon activation, caspases appear to play an important role in sequelae of traumatic brain injury, spinal cord injury and cerebral iischemia. In addition, they may also play a role in mediating cell death in chronic neurodegenerative conditions such as Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Are there any issues with using sc-56038: caspase-11 (17D9) mouse monoclonal primary antibody on mouse samples?
Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-56038 conjugates.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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