Casein Kinase II Inhibitor III, TBCA CAS: 934358-00-6
MF: C9H4Br4O2
MW: 463.8
A potent, cell-permeable Casein Kinase II inhibitor.

Casein Kinase II Inhibitor III, TBCA (CAS 934358-00-6)

Casein Kinase II Inhibitor III, TBCA | CAS 934358-00-6 is rated 5.0 out of 5 by 1.
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Alternate Names: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
Application: Casein Kinase II Inhibitor III, TBCA is a potent, cell-permeable Casein Kinase II inhibitor
CAS Number: 934358-00-6
Purity: >95%
Molecular Weight: 463.8
Molecular Formula: C9H4Br4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Casein Kinase II Inhibitor III, TBCA is a cell-permeable serine/ threonine kinase that is a tetrabrominated cinnamic acid compound. Casein Kinase II Inhibitor III, TBCA acts as an ATP-competitive and potent inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than DMAT and TBB (sc-202830) against a panel of 28 commonly studied kinases. Studies show that it induces apoptosis in Jurkat cells (DC50 = 7.7 μM) more efficiently than DMAT.


References

1. Pagano, M.A., et al. 2006. Biochem. Soc. Trans. 34: 1303-1306. PMID: 17073807
2. Pagano, M.A., et al. 2007. Chembiochem. 8: 129-139. PMID: 17133643
3. López-Ramos, M., et al. 2010. FASEB J. PMID: 20400536
4. Qaiser, F. et al. 2014. J. Cell. Biochem. 115(12): 2103-2115. PMID: 25043911

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ethanol (5 mg/ml).
Storage :
Store at 4° C
Melting Point :
174.54° C (Predicted)
Boiling Point :
490.80° C at 760 mmHg (Predicted)
Density :
2.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
Casein Kinase II: IC50 = 110 nM; Interferon-induced, double-stranded RNA-activated protein kinase: IC50 = 7 µM (human)
Ki Data :
Casein Kinase II: Ki= 77 nM
pK Values :
pKa: 3.83
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=C(C(=C(C(=C1Br)Br)Br)Br)/C=C/C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Casein Kinase II Inhibitor III, TBCA (CAS 934358-00-6)  Product Citations

See how others have used Casein Kinase II Inhibitor III, TBCA (CAS 934358-00-6). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 24576828  Kho, DH. et al. 2014. Cancer Res. 74: 2229-37.

PMID: # 22488351  Deng, H. et al. 2012. Pharmacology. 89: 211-9.

PMID: # 17073807  Pagano, MA. et al. 2006. Biochem. Soc. Trans. 34: 1303-1306.

PMID: # 28542923  J Neurochem. 392-406.

PMID: # 26530072  Dokl Biol Sci. 260-2.

PMID: # 32729988  FASEB J.

PMID: # 27788493  Oncotarget. 77937-77949.

PMID: # 32751444  Int J Mol Sci.

PMID: # 29520715  Mol. Neurobiol. 55: 8203-8215.

Citations 1 to 9 of 9 total

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Casein Kinase II Inhibitor III, TBCA (CAS 934358-00-6), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Qaiser Qaiser, F. et al. (PubMed 25043911) used TBCA (Casein Kinase II Inhibitor III) to demonstrate that CKII inhibition induces cell death via early impact on mitochondrial function. -SCBT Publication Review
Date published: 2015-02-28
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