Carnosic acidAn antioxidant, lipid peroxidation inhibitor, and PPARγ activator

Carnosic acid (CAS 3650-09-7)

Carnosic acid | CAS 3650-09-7 is rated 3.0 out of 5 by 2.
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Synonym: Salvin
Application: An antioxidant, lipid peroxidation inhibitor, and PPARγ activator
CAS Number: 3650-09-7
Purity: ≥95%
Molecular Weight: 332.43
Molecular Formula: C20H28O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Carnosic acid is a diterpenoid that acts as an effective lipid peroxidation inhibitor in liposomal and microsomal environments, with antioxidant properties. Carnosic acid has been reported to scavenge peroxyl radicals, H2O2, reduce cytochrome C, and act more potently than Propyl gallate (sc-250794). Studies indicate that Carnosic acid protects red cells from oxidative hemolysis and in the xanthine/xanthine oxidase system inhibits superoxide anion production. In addition, data suggests that Carnosic acid activates PPARγ (peroxisome proliferator activated receptor γ).


References

1. Aruoma, O I., et al., 1992. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica; the fate of foreign compounds in biological systems. 22(2): 257-68. PMID: 1378672
2. Schwarz, K., et al., 1992. Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. 195(2): 99-103. PMID: 1529648
3. Haraguchi, H., et al., 1995. Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis. Planta medica. 61(4): 333-6. PMID: 7480180
4. Geoffroy, M., et al., 1994. Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids. Free radical research. 21(4): 247-58. PMID: 7827696
5. Kuzmenko, A I., et al., 1999. Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid. Journal of photochemistry and photobiology. B, Biology. 48(1): 63-7. PMID: 10205880
6. Rau, Oliver., et al., 2006. Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma. Planta medica. 72(10): 881-7. PMID: 16858665

Appearance :
Powder
Physical State :
Solid
Derived From :
Rosmarinus officinalis
Solubility :
Soluble in water (partly), and DMSO.
Storage :
Store at -20° C
Melting Point :
190° C (lit.)
Boiling Point :
499-503° C
Density :
~1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D 184°, c = 1 in methanol
IC50 :
HIV1 protease: IC50 = 0.24 µM (human); MRC5: IC50 = 21.8 µM (human); Pancreatic lipase: IC50 = 36 µM (human); HepG2: IC50 = 41.3 µM (human); AGS: IC50 = 89.8 µM (human)
pK Values :
pKa: 4.14 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
65126
MDL Number :
MFCD02259459
EC Number :
609-253-7
Beilstein Registry :
2707918
SMILES :
CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C(=O)O)O)O

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Certificate of Analysis

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Carnosic acid  Product Citations

See how others have used Carnosic acid. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27212017  Jung, KJ. et al. 2016. Free radical biology & medicine. 97: 50-57.

PMID: # 25596735  Jung, KJ. et al. 2015. Oncotarget. 6: 1556-68.

PMID: # 25038454  Lipina, C. et al. 2014. Cellular signalling. 26: 2343-9.

PMID: # 25337586  Min, KJ. et al. 2014. J Cancer Prev. 19: 170-178.

Citations 1 to 4 of 4 total

Dear SantaCruzz members, I am a research assitant in Eskisehir Medicine School. I have a project having 4000 dollar budget. I will already buy many materials. I cannot afford carnosic acid, it is too expensive. Is it possible to provide me 2-3 g?

Asked by: Needhope
Thank you for your question. The smallest quantity we can provide of Carnosic acid: sc-202520 is 10 mg.
Answered by: Technical Support
Date published: 2017-06-30

We need information about the preparation steps of carnosic acid for cell culture studies and the details of how we can add carnosic acid to the culture medium as a sterilised soluble agent. Thanks in advance for your kind interest.

Asked by: Ranan Gulhan Aktas
Thank you for your question. We are unable to offer any specific recommendation on how to use Carnosic acid (CAS#3650-09-7) for cell culture studies. This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood. [If there is a graded product that you would like us to consider adding, please provide a technical service representative with all of the pertinent information needed including, name, CAS number, size, number of vials needed, grade/expected uses, and any additional information like, purity/potency and native source.] We would recommend you search in the primary literature to see how other investigators are using the chemical for this purpose. There are a few references listed on our website that may be a useful place to start your research: 1. Aruoma, O I., et al., 1992. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica; the fate of foreign compounds in biological systems. 22(2): 257-68. PMID: 1378672 2. Schwarz, K., et al., 1992. Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. 195(2): 99-103. PMID: 1529648 3. Haraguchi, H., et al., 1995. Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis. Planta medica. 61(4): 333-6. PMID: 7480180 4. Geoffroy, M., et al., 1994. Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids. Free radical research. 21(4): 247-58. PMID: 7827696 5. Kuzmenko, A I., et al., 1999. Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid. Journal of photochemistry and photobiology. B, Biology. 48(1): 63-7. PMID: 10205880 6. Rau, Oliver., et al., 2006. Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma. Planta medica. 72(10): 881-7. PMID: 16858665 If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-03-07
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Rated 1 out of 5 by from after 8 weeks haven't seen the Carnosic acid have been waiting for almost two months for ordered carnosic acid and carnosol to be sent with no feedback from SCBT
Date published: 2017-12-18
Rated 5 out of 5 by from Wang Wang, T. et al. (PubMed 26223904) demonstrated that Carnosic acid protects against oxidative stress-induced cytotoxicity via SIRT1 by regulating downstream factors such as ERK1/2. -SCBT Publication Review
Date published: 2015-03-31
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