Carmustine is a member of the antineoplastic nitrosourea compounds. Carmustine can perform both alkylating and carabamoylating action and owes part of its cytotoxicity to its demonstrated ability to produce interstrand DNA cross linking. In addition, this compound has been documented as an inhibitor of glutathione reductase, trypanothione reductase, and lipoamide dehydrogenase (DLD).
1. Schabel, F.M. 1976. Cancer Treat Rep. 60: 665-698. PMID: 782694 2. Puglia, C.D., et al. 1984. Environ. Health Perspect. 57: 307-311. PMID: 6094175 3. Lohrer, H. and Krauth-Siegel, R.L. 1990. Eur. J. Biochem. 194: 863-869. PMID: 2269305 4. Arscott, L.D., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 3621-3626. PMID: 9108027 5. Pratt, B.W., et al. 1994. The Anticancer Drugs. Oxoford Universtiy Press Inc. N.Y., N.Y.
Soluble in water (4 mg/ml), and 50% ethanol (150 mg/ml).
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Answered by: Tech Service 8
Date published: 2017-01-19
CAS 154-93-8 产品如何购买？货期大概多长？
Asked by: Krystal
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Rated 5 out of
Tseng YY; et alTseng YY; et al. (PubMed ID: 26209775) determined that Carmustine, when released with biodegradable drug-eluting nanofibrous membranes, enhances the effectivity of this chemotherapuetic drug. -SCBT Publication Review
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