CariporideAn NHE-1 inhibitor that blocks apoptosis in cardiac muscle cells

Cariporide (CAS 159138-80-4)

Cariporide | CAS 159138-80-4 is rated 5.0 out of 5 by 1.
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Synonym: N-(Diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide
Application: An NHE-1 inhibitor that blocks apoptosis in cardiac muscle cells
CAS Number: 159138-80-4
Purity: ≥98%
Molecular Weight: 283.35
Molecular Formula: C12H17N3O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cariporide is a NHE-1 (sodium-hydrogen exchanger isoform-1) inhibitor. Rat studies indicate that cariporide blocks apoptosis of cardiac muscle cells. Additional studies show that the compound interacts with and weakens mitochondrial Ca2+ overload and the permeability transition pore (PTP).


References

1. Toda, T., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H3517-H3523. PMID: 17906113
2. Luo, F.Y., et al. 2008. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 33: 507-511. PMID: 18599998
3. McAllister, S.E., et al. 2009. J. Appl. Physiol. 106: 20-28. PMID: 19023020
4. Ayoub, I.M., et al. 2010. Resuscitation. 81: 106-110. PMID: 19853351

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at room temperature
Melting Point :
188.43° C (Predicted)
Boiling Point :
542° C at 760 mmHg
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Sodium/hydrogen exchanger 1: IC50 = 26 nM (Oryctolagus cuniculus); Sodium/hydrogen exchanger 3: IC50 = 26 nM (Oryctolagus cuniculus); Sodium/hydrogen exchanger 2: IC50 = 26 nM (Oryctolagus cuniculus); nM: IC50 = 30.7 nM (Rattus norvegicus)
pK Values :
pKb: 4.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
151172
MDL Number :
MFCD00864683
SMILES :
CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Cariporide  Product Citations

See how others have used Cariporide. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 17 total

PMID: # 28943936  Altaf, E. et al. 2017. Oncol Lett. 14: 4256-4262.

PMID: # 27488617  Hardonnière, K. et al. 2016. Sci Rep. 6: 30776.

PMID: # 27035656  Tauber, P. et al. 2016. Endocrinology. en20152029.

PMID: # 25118990  Peetz, J. et al. 2015. Pflugers Arch. 467: 1469-80.

PMID: # 26418325  Stindl, J. et al. 2015. Endocrinology. 156: 4582-91.

PMID: # 25724898  Wang, J. et al. 2015. Exp. Cell Res. 333: 60-72.

PMID: # 25522216  Park, SY. et al. 2015. J. Cell. Physiol. 230: 1503-14.

PMID: # 26086121  Hardonnière, K. et al. 2015. Toxicol In Vitro. 29: 1597-608.

PMID: # 24827113  Lee, ZW. et al. 2014. Br. J. Pharmacol. 171: 4322-36.

PMID: # 25139834  Sakurai, S. et al. 2014. Life Sci. 114: 102-6.

Citations 1 to 10 of 17 total
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Rated 5 out of 5 by from Ayoub et al Ayoub et al. (PubMed ID 19853351) found that Cariporide inhibited NHE-1 and ameliorated post-resuscitation ventricular ectopic activity and helped restore stable circulation after resuscitation from cardiac arrest. -SCBT Publication Review
Date published: 2015-05-24
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