A chalone analog that display anti-inflammatory activity. Has been shown to inhibit NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Also has been shown to inhibit NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.
Lee et al (2006) Blockade of nuclear factor-kB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271. Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188. Israf et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673.
Rated 5 out of
De Castro et alDe Castro et al. (PubMed ID 26321741) found that cardamonin, a schistosomicidal chalcone, successfully inhibited S. mansoni ATP diphosphohydrolase activity. -SCBT Publication Review
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