Cardamonin

Cardamonin (CAS 19309-14-9)

Cardamonin | CAS 19309-14-9 is rated 5.0 out of 5 by 1.
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Synonym: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; Alpinetin chalcone
Application: CAS: 19309-14-9, MF: C16H14O4, MW: 270.28, Purity: ≥98%
CAS Number: 19309-14-9
Purity: ≥98%
Molecular Weight: 270.28
Molecular Formula: C16H14O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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A chalone analog that display anti-inflammatory activity. Has been shown to inhibit NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Also has been shown to inhibit NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.


References

Lee et al (2006) Blockade of nuclear factor-kB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271. Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188. Israf et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Store at 4° C
Melting Point :
177.58° C (Predicted)
Boiling Point :
~484.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
KV1.3: IC50 = 2 nM (human); DLD-1: IC50 = 41.8 µM (human)
Ki Data :
Dengue virus type 2 NS3 protein: Ki= 377 µM
pK Values :
pKa: 7 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
641785
MDL Number :
MFCD00238554
SMILES :
COC1=CC(=CC(=C1C(=O)/C=C/C2=CC=CC=C2)O)O

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a yellow crystalline powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-02-06
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Rated 5 out of 5 by from De Castro et al De Castro et al. (PubMed ID 26321741) found that cardamonin, a schistosomicidal chalcone, successfully inhibited S. mansoni ATP diphosphohydrolase activity. -SCBT Publication Review
Date published: 2015-05-05
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