A highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carriers. For example, adenine nucleotide translocase (ANT) causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and eventually apoptosis.
Notario, B., et al., All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition. Mol. Pharmacol. 63, 224-231, (2003)