A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. Carbonyl Cyanide m-Chlorophenylhydrazone, a protonophore and an inhibitor of ER-Golgi protein transport, has been reported to bind to Cytochrome C oxidase with a high affinity. In experiments done on bullfrog sympathetic ganglia, this compound increased spontaneous release of luteinizing hormone-releasing hormone, which strongly depended on firing frequency. Other studies suggest that Carbonyl Cyanide m-Chlorophenylhydrazone is also a proton conductor that could greatly affect E.coli cell viability in the presence of glucose.
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See how others have used Carbonyl Cyanide m-Chlorophenylhydrazone (CAS 555-60-2). Click on the entry to view the PubMed entry .
PMID: # 30716103 Kakimoto, PA.|Chausse, B.|Caldeira da Silva, CC.|Donato Júnior, J.|Kowaltowski, AJ.| et al. 2019. PLoS ONE. 14: e0211733.
PMID: # 27778331 Barbado, MV. et al. 2017. Int. J. Cancer. 140: 674-685.
PMID: # 25146533 Tan, JW. et al. 2016. Environ. Toxicol. 31: 224-32.
PMID: # 26512954 Shi, J. et al. 2015. Cell death & disease. 6: e1943.
PMID: # 25506911 Jo, H. et al. 2014. PLoS ONE. 9: e115362.
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