Carbocyclic Thromboxane A2(CTA2) is a stable analog of TXA2 which acts as a potent coronary vasoconstrictor at low concentrations. Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation, specifically arachidonic acid-induced aggregation (IC50 = 4-5 µM). CTA2 also exhibits dose-dependent and selective inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 µM.
1. Lefer, A M., et al., 1980. Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. Proceedings of the National Academy of Sciences of the United States of America. 77(3): 1706-10. PMID: 6929517
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