Carbocyclic Thromboxane A2A stable analog of TXA2 which inhibits platelet aggregation

Carbocyclic Thromboxane A2 (CAS 74034-56-3)

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Synonym: Carbocyclic TXA2; CTA2
Application: A stable analog of TXA2 which inhibits platelet aggregation
CAS Number: 74034-56-3
Molecular Weight: 348.52
Molecular Formula: C22H36O3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Carbocyclic Thromboxane A2(CTA2) is a stable analog of TXA2 which acts as a potent coronary vasoconstrictor at low concentrations. Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation, specifically arachidonic acid-induced aggregation (IC50 = 4-5 µM). CTA2 also exhibits dose-dependent and selective inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 µM.


References

1. Lefer, A M., et al., 1980. Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. Proceedings of the National Academy of Sciences of the United States of America. 77(3): 1706-10. PMID: 6929517

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (>0.1 mg/ml at 25.0° C), DMSO (~25 mg/ml), DMF (~25 mg/ml), PBS(pH 7.2) (~0.1 mg/ml), and ethanol.
Storage :
Store at -20° C
Boiling Point :
78° C
IC50 :
Arachidonic acid-induced aggregation: IC50 = 4-5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CCCCCC(O)/C=C/[C@H]1CC2CC(C2)C1C/C=C\\CCCC(=O)O

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Carbocyclic Thromboxane A2  Product Citations

See how others have used Carbocyclic Thromboxane A2. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 15015658  Matsuo, M. et al. 2004. J. Neurooncol. 66: 285-292.

Citations 1 to 1 of 1 total
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