Carbenoxolone disodiumAn inhibitor of 11 β-hydroxysteroid dehydrogenase (11β-HSD)

Carbenoxolone disodium (CAS 7421-40-1)

Carbenoxolone disodium | CAS 7421-40-1 is rated 5.0 out of 5 by 3.
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Synonym: 3β-Hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate
Application: An inhibitor of 11 β-hydroxysteroid dehydrogenase (11β-HSD)
CAS Number: 7421-40-1
Purity: ≥98%
Molecular Weight: 614.72
Molecular Formula: C34H48O72Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Carbenoxolone disodium is a glucocorticoid that inhibits 11β-HSD (11β-hydroxysteroid dehydrogenase) and blocks gap juntion communication.


References

Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209. Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543.

Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml).
Storage :
Desiccate at 4° C
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
11-β-hydroxysteroid dehydrogenase 2: IC50 = 82 nM (mouse); 11β-HSD1: IC50 = 83 nM (human); 11β-HSD1: IC50 = 108 nM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RK0250000
PubChem CID :
636402
Merck Index :
14: 1793
MDL Number :
MFCD00079043
EC Number :
231-044-0
SMILES :
C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CCC(=O)[O-])C)(C)C(=O)[O-].[Na+].[Na+]

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Certificate of Analysis

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Carbenoxolone disodium (CAS 7421-40-1) If I order it now, when will it be shipped?

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Answered by: Technical Support
Date published: 2019-02-10
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Rated 5 out of 5 by from high quality The quality is very good, let me successfully completed the experiment, recommend everyone to use
Date published: 2016-11-06
Rated 5 out of 5 by from Lots of products to help you with your research Lots of products to help you with your research from antibodies to expression vectors and labeling reagents. Not anything you couldn't find anywhere else
Date published: 2015-10-26
Rated 5 out of 5 by from Zou H; et al Zou H; et al. (PubMed ID: 26165643): determined that Carbenoxolone disodium, a gap junction blocker, protected BRL 3A rat liver cells from (Cd)-induced hepatotoxicity. -SCBT Publication Review
Date published: 2015-04-25
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