CaptoprilA competitive inhibitor of LTA4 hydrolase and other enzymes

Captopril (CAS 62571-86-2)

Captopril | CAS 62571-86-2 is rated 5.0 out of 5 by 1.
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Synonym: Capoten;L-Captopril
Application: A competitive inhibitor of LTA4 hydrolase and other enzymes
CAS Number: 62571-86-2
Purity: ≥98%
Molecular Weight: 217.28
Molecular Formula: C9H15NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.


References

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10. No authors listed. 1999. Curr. Hypertens. Rep. 1: 466-467. PMID: 11041675
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12. Nikolova, J.G., et al. 2000. Folia Med. 42: 47-51. PMID: 10979177
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Appearance :
Powder or crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (160 mg/ml) at 25° C, sesame and corn oils (<1 mg/ml) at 25° C, methanol (>100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml).
Storage :
Store at room temperature
Melting Point :
104-108° C (lit.)
Boiling Point :
~427.04° C at 760 mmHg (Predicted)
Density :
~1.27 g/cm3 (Predicted)
Refractive Index :
n20D 1.55
Optical Activity :
α22/D -131°, c = 1.7 in ethanol
IC50 :
angiotensin converting enzyme: IC50 = 0.021 ± 0.013 µM (porcine kidney); LTA4 hydrolase: IC50 = 11 µM; apoptosis in human lung epithelial cells: IC50 = ~ 320 nM (human lung epithelial cells)
Ki Data :
Angiotensin-converting enzyme: Ki= 1.7 nM (Homo sapiens); Thrombin: Ki= 48 nM (Homo sapiens); Renin: Ki= 1.7 nM (Homo sapiens); Succinyl-diaminopimelate desuccinylase: Ki= 1820 nM (Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd))
pK Values :
pKa: pK1: 3.7, pK2: 9.8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UY0550000
PubChem CID :
44093
Merck Index :
14: 1774
MDL Number :
MFCD00168073
EC Number :
263-607-1
Beilstein Registry :
477887

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Captopril  Product Citations

See how others have used Captopril. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 30602301  Zhou, Z.|Peters, AM.|Wang, S.|Janda, A.|Chen, J.|Zhou, P.|Arthur, E.|Kwartler, CS.|Milewicz, DM.| et al. 2019. Arterioscler. Thromb. Vasc. Biol. 39: 459-466.

PMID: # 27220756  Trojanowicz, B. et al. 2016. Nephrol. Dial. Transplant.

PMID: # 25925093  2015. J. Neurovirol. 21: 480-90.

PMID: # 25003524  2014. PLoS ONE. 9: e102137.

PMID: # 22261727  Rani, MP. et al. 2012. J. Sci. Food Agric. 92: 1948-55.

Citations 1 to 5 of 5 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Captopril, sc-200566, is soluble in DMSO at 43 mg/mL, water at 2 mg/mL, and ethanol at 43 mg/mL.
Answered by: TechService7
Date published: 2017-01-24
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Rated 5 out of 5 by from Medjadba W; et al Medjadba W; et al. (PubMed ID: 26361946) determined that Captopri, a kininase II inhibitor, partially reduced some cardiac disorders. -SCBT Publication Review
Date published: 2015-04-23
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