CapsaicinA TRPV1 receptor agonist

Capsaicin (CAS 404-86-4)

Capsaicin | CAS 404-86-4 is rated 5.0 out of 5 by 1.
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Synonym: trans-8-Methyl-n-vanillyl-6-nonenamide
Application: A TRPV1 receptor agonist
CAS Number: 404-86-4
Purity: ≥98%
Molecular Weight: 305.4
Molecular Formula: C18H27NO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Capsaicin acts as an agonist at the VR1 (TRPV1) receptor, a ligand-gated non-selective cation channel. It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons. Capsaicin also Inhibits NFκB activation by TNF and reversibly inhibits platelet aggregation. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.


References

1. Pegorini, S., et al. 2005. Br. J. Pharmacol. 144: 727-735. PMID: 15678080
2. Pingle, S.C., et al. 2007. Handb. Exp. Pharmacol. 179: 155-171. PMID: 17217056
3. Ma, W. and Quirion, R. 2007. Expert Opin. Ther. Targets. 11: 307-320. PMID: 17298290
4. Bevan, S. and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11: 330-333. PMID: 2203194
5. Pernow, B., et al. 1985. J. Immunol. 135: 812s-815s. PMID: 2409169

Usage :
Capsaicin is slightly soluble in Chloroform and Ethyl Acetate.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (≥30 mg/mL), ether, chloroform, benzene, DMSO (≥30 mg/mL), DMF (≥30 mg/mL), and PBS (pH 7.2) (≥0.1 mg/mL). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
62-65° C (lit.)
Boiling Point :
210-220° C
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
Vanilloid receptor: IC50 = 19 nM (Rattus norvegicus)
pK Values :
pKa: 9.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RA8530000
PubChem CID :
1548943
Merck Index :
14: 1768
MDL Number :
MFCD00017259
EC Number :
206-969-8
Beilstein Registry :
2816484
SMILES :
CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

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Certificate of Analysis

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Capsaicin  Product Citations

See how others have used Capsaicin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 28795251  2018. Mol. Cell. Biochem. 439: 189-198.

PMID: # 26099309  Özdemir, ÜS. et al. 2015. Mol. Neurobiol.

PMID: # 25743251  Nazıroğlu, M. et al. 2015. Neuroscience. 293: 55-66.

PMID: # 18554636  Chuang, YC. et al. 2008. J. Urol. 180: 742-748.

PMID: # 18482991  Vetter, I. et al. 2008. J. Biol. Chem. 283: 19540-19550.

PMID: # 17141941  Chuang, YC. et al. 2007. Eur. Urol. 51: 1119-1127.

PMID: # 17656446  Eijkelkamp, N. et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G749-G757.

PMID: # 16725275  Rau, KK. et al. 2006. Neuroscience. 141: 955-963.

PMID: # 16236247  Hwang, JT. et al. 2005. Biochem. Biophys. Res. Commun. 338: 694-699.

PMID: # 15793280  Bodo, E. et al. 2005. Am J Pathol. 166: 985-998.

Citations 1 to 10 of 13 total

Hello - what is the source of this raw material (i.e. country of origin)? Thank you!

Asked by: Heather24
Thank you for your question. This may be lot-specific information. Please contact our Technical Service Department to require about a specific lot number, or information about the current lot.
Answered by: Technical Support
Date published: 2019-04-13

Is this product naturally derived or synthetic?

Asked by: 13punMA
Thank you for your question concerning our product Capsaicin (CAS# 404-86-4). The Capsaicin that we is from a natural source.
Answered by: Chemical Support 8
Date published: 2017-03-02

Would dihydrocapsaicin be removed from the capsaicin under the resolving conditions that it was purified?

Asked by: 13punMA
Thank you for the question about our product Capsaicin (CAS# 404-86-4). We do not know specifically if the product will be completely free of dihydrocapsacin.
Answered by: Chemical Support 8
Date published: 2017-03-02

What is Capsaicin derived from?

Asked by: SCchem16
This product is derived from chili peppers.
Answered by: Tech Service 4
Date published: 2016-12-17
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Rated 5 out of 5 by from Liu Liu, et. al. (PubMed ID 18553211) used capsaicin at various concentrations and time intervals to study its effect on galanin and galanin receptor 2 expression in primary cultured dorsal root ganglion neurons. -SCBT Publication Review
Date published: 2015-02-23
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