CapecitabineAn antiproliferative 5-fluorouracil releasing compound

Capecitabine (CAS 154361-50-9)

Capecitabine | CAS 154361-50-9 is rated 5.0 out of 5 by 1.
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Application: An antiproliferative 5-fluorouracil releasing compound
CAS Number: 154361-50-9
Purity: ≥98%
Molecular Weight: 359.35
Molecular Formula: C15H22FN3O6
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Capecitabine inhibits DNA synthesis and slows growth of tumor tissue upon enzymatic conversion to 5-fluorouracil in the tumor.


References

1. Fischer, D.S., et al. 2003. The Cancer Chemotherapy Handbook. 6th Ed. Philadelphia, Pennsylvania. Mosby.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (26 mg/ml), ethanol (207 mg/ml), methanol (> 40%), DMF (~14 mg/ml), and DMSO (72 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
115-120° C
Boiling Point :
517° C (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.6 (Predicted)
IC50 :
RKOp27 cells : IC50 = 4.33 nM (human); HeLa: IC50 = 50 ug/mL (human); NCI-H69: IC50 = 300 ug/mL (human); MCF7: IC50 = 710 ug/mL (human)
pK Values :
pKa: 5.41 (Predicted), pKb: 1.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
HA3852500
PubChem CID :
60953
MDL Number :
MFCD00930626
SMILES :
FC=1\\C(=N/C(=O)N(C=1)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)C)\\NC(=O)OCCCCC

Download SDS (MSDS)

Certificate of Analysis

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Capecitabine  Product Citations

See how others have used Capecitabine. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 27056620  Kobashi, N. et al. 2016. Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

PMID: # 27814544  Isidori, M. et al. 2016. Environ. Pollut. 219: 275-287.

PMID: # 26971211  Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.

PMID: # 26416623  Lehouritis, P. et al. 2015. Sci Rep. 5: 14554.

PMID: # 25124055  Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.

PMID: # 24727039  Parrella, A. et al. 2014. The Science of the total environment. 485-486: 216-22.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24148406  2013. Talanta. 116: 290-9.

PMID: # 23357749  Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.

Citations 1 to 9 of 9 total

How stable are Capecitabine and 5-FdU in solution when stored at 4'C?

Asked by: Isabella
Capecitabine can be stored as a solution in tightly sealed vials if stored at -20ºC, and should be used within one month, but if possible solutions should be made and used on the same day.
Answered by: Technical Support
Date published: 2019-09-11

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The chemical, sc-205618, is provided as a white or almost-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-11

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. In water, it is soluble at 26 mg/ml, but it is freely soluble in ethanol at 207 mg/ml. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-19
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Rated 5 out of 5 by from Simmer et al Simmer et al. (PubMed ID 26392389) found that metastatic colorectal cancer patients treated with the antiproliferative, Capecitabine decreased the tumor expression of miR-143. -SCBT Publication Review
Date published: 2015-02-07
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