Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Calpains are calcium-activated thiol proteases. Calpain 7 (also known as PalBH) is a member of the Non-EF-hand subfamily of calpains and may be calcium independent. Calpain 7 has 813 amino acid residues and is a divergent member of the calpain family. It has only 26-35% shared identity to other members and most of this homology is in the protease domain. Calpain 7 seems to be related to PalB, an Aspergillus nidulans protease that is involved in alkaline ambient pH adaptation. A long N-terminal domain (N) and a PalB homologous domain (PBH) flank the calpain protease domain of calpain 7. Calpain 7 appears to have a ubiquitous tissue distribution but is highly expressed in the brain. It localizes to the cytoplasm and the nucleus, but its activated form is found only in the nucleus. Calpain 7 is an atypical calpain that lacks domain IV and cannot form a dimer with the 30 kDa regulatory subunit. Upregulation of Calpain 7 in striatal or cortical tissue of Huntington's Disease knock-in mice suggests that this protein may be involved in the onset of the disease.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.