Calindol hydrochlorideA new calcimimetic compound acting at the calcium sensing receptor

Calindol hydrochloride (CAS 729610-18-8)

Calindol hydrochloride | CAS 729610-18-8 is rated 5.0 out of 5 by 1.
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Synonym: N-[(1R)-1-(1-Naphthalenyl)ethyl]-1H-indole-2-methanamine Hydrochloride; (R)-2-[[[1-(1-Naphthyl)ethyl]amino]methyl]-1H-indole Hydrochloride
Application: A new calcimimetic compound acting at the calcium sensing receptor
CAS Number: 729610-18-8
Purity: ≥98%
Molecular Weight: 336.86
Molecular Formula: C21H20N2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Calindol hydrochloride is a new calcimimetic compound acting at the calcium sensing receptor. It is a positive allosteric modulator of the human Ca2+ receptor which activates an extracellular ligand-binding domain-deleted, Rhodopsin-like, seven-transmembrane structure in the absence of Ca2+.


References

Fawzi, A., et al.: Biochemistry, 29, 3804 (1990), Han, G., et al.: J. Biol. Chem., 274, 10008 (1999), Palczewski, K., et al.: Science, 289, 739 (2000), Nemeth, E., et al.: J. Pharmacol. Exp. Ther., 299, 323 (2001), Kew, J., et al.: Pharmacol. Ther., 104, 233 (2004),

Physical State :
Solid
Solubility :
Soluble in Chloroform and Methanol
Storage :
Store at 4° C
Melting Point :
208-210° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23544608
SMILES :
C[C@H](C1=CC=CC2=CC=CC=C21)NCC3=CC4=CC=CC=C4N3.Cl

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Certificate of Analysis

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Calindol hydrochloride  Product Citations

See how others have used Calindol hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30906225  Zhang, X.|Hong, S.|Qi, S.|Liu, W.|Zhang, X.|Shi, Z.|Chen, W.|Zhao, M.|Yin, X.| et al. 2019. Mediators Inflamm. 2019: 6847087.

PMID: # 29128361  Zhang, X.|Chen, W.|Li, J.|Qi, S.|Hong, S.|Wang, Y.|Gao, L.|Shi, Z.|Liu, Y.|Liu, W.|Chi, Y.|Liu, C.|Fu, Y.|Yin, X.| et al. 2018. Biochem. Biophys. Res. Commun. 495: 454-460.

PMID: # 28215313  Kato, M. et al. 2017. Nutrition research (New York, N.Y.). 37: 37-45.

PMID: # 26510380  Vancleef, L. et al. 2015. Scientific reports. 5: 15725.

PMID: # 23269670  Oya, M. et al. 2013. J. Biol. Chem. 288: 4513-21.

PMID: # 23548867  Ciceri, P. et al. 2012. Nephron. Experimental nephrology. 122: 75-82.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Zhong Zhong, X. et al. (PubMed 25824457) used the calcium-sensing receptor (CaSR) agonist Calindol, to determine whether CaSR inhibits the proliferation of vascular smooth muscle cells by regulating the endogenous cystathionine-gamma-lyase/hydrogen sulfide pathway in diabetic rats. -SCBT Publication Review
Date published: 2015-02-28
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