Caged Retinoic Acid is a photoactivatable form of Retinoic Acid (sc-200898). Retinoic Acid is the oxidized carboxylic acid form of retinol, known in the dietary context as Vitamin A. Retinal (sc-210778) is the aldehyde form of retinol required by the retina of the eye for light absorption and visual processing. Retinoic acid and the other retinoids are involved in a broad range of biological regulations, mediating differentiation, proliferation, and apoptosis. Binding of Retinoic Acid to the nuclear receptors retinoic acid receptor (RAR) and the retinoid X receptor (RXR) initiate signals for transcription and development. The intimate relationship between retinoids and cell cycle regulation has been implicated in suppression of oncogenic proliferation. Also available as a non-caged form, Retinoic Acid (sc-200898).
1. Neveu, P., et al. 2008. Angew. Chem. Int. Ed. Engl. 47: 3744-3746. PMID: 18399559
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