cADP-Ribose, a nicotamide adenine dinucleotide (NAD+) metabolite, is an agent extracted from sea urchin eggs and has been shown to mobilize intracellular Ca2+ stores of the eggs. Additionally, in a study on pancreatic beta cells, cADP-Ribose was found to be generated in islets by glucose stimulation, and served as a second messenger for calcium mobilization in the endoplasmic reticulum. Other experiments have reported cADP-Ribose to be a signaling molecule in abscisic acid response in plants, which mediates plant responses to stresses such as salinity, cold, and drought.
1. Lee, H.C., et al. 1989. J. Biol. Chem. 264: 1608-1615. PMID: 2912976 2. Takasawa, S., et al. 1993. Science. 259: 370-373. PMID: 8420005 3. Wu, Y., et al. 1997. Science. 278: 2126-2130. PMID: 9405349
Soluble in water (25 mg/ml), and DMSO.
Store at -20° C
~934.8° C at 760 mmHg (Predicted)
~2.6 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
WuWu, Y. et al. (PubMed 9405349) performed bioassay experiments that showed that the amounts of cADPR in Arabidopsis thaliana plants increased in response to abscisic acid (ABA) treatment and before ABA-induced gene expression. -SCBT Publication Review
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