cADP-Ribose (cADPR)A potent second messenger for Ca22+ and a signaling molecule in abscisic acid response in plants

cADP-Ribose (cADPR) (CAS 119340-53-3)

cADP-Ribose (cADPR) | CAS 119340-53-3 is rated 5.0 out of 5 by 1.
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Synonym: Cyclic Adenosine Diphosphate Ribose
Application: A potent second messenger for Ca22+ and a signaling molecule in abscisic acid response in plants
CAS Number: 119340-53-3
Purity: ≥90%
Molecular Weight: 541.30
Molecular Formula: C15H21N5O13P2
* Refer to Certificate of Analysis for lot specific data (including water content).
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cADP-Ribose, a nicotamide adenine dinucleotide (NAD+) metabolite, is an agent extracted from sea urchin eggs and has been shown to mobilize intracellular Ca2+ stores of the eggs. Additionally, in a study on pancreatic beta cells, cADP-Ribose was found to be generated in islets by glucose stimulation, and served as a second messenger for calcium mobilization in the endoplasmic reticulum. Other experiments have reported cADP-Ribose to be a signaling molecule in abscisic acid response in plants, which mediates plant responses to stresses such as salinity, cold, and drought.


References

1. Lee, H.C., et al. 1989. J. Biol. Chem. 264: 1608-1615. PMID: 2912976
2. Takasawa, S., et al. 1993. Science. 259: 370-373. PMID: 8420005
3. Wu, Y., et al. 1997. Science. 278: 2126-2130. PMID: 9405349

Appearance :
Lyophilized powder
Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), and DMSO.
Storage :
Store at -20° C
Boiling Point :
~934.8° C at 760 mmHg (Predicted)
Density :
~2.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.96
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
123847
MDL Number :
MFCD00214262
SMILES :
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=CN(C4=N)[C@H]5[C@@H]([C@@H]([C@H](O5)COP(=O)(OP(=O)(O1)O)O)O)O)O)O

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Certificate of Analysis

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cADP-Ribose (cADPR)  Product Citations

See how others have used cADP-Ribose (cADPR). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28295574  Hattori, T. et al. 2017. Glia. 65: 974-989.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Wu Wu, Y. et al. (PubMed 9405349) performed bioassay experiments that showed that the amounts of cADPR in Arabidopsis thaliana plants increased in response to abscisic acid (ABA) treatment and before ABA-induced gene expression. -SCBT Publication Review
Date published: 2015-03-27
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