C8 Ceramine, D-erythroAn analog of ceramide

C8 Ceramine, D-erythro (CAS 170926-06-4)

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Synonym: (2S,3R,4E)-2-(Octylamino)-4-octadecene-1,3-diol
Application: An analog of ceramide
CAS Number: 170926-06-4
Molecular Weight: 411.70
Molecular Formula: C26H53NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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C8 Ceramine, D-erythro is an analog of ceramide in which the amide is substituted with an amine. This substitution renders it inert to ceramidases. It is highly effective at induction of apoptosis in U937 cells. Ceramine induces peak DNA fragmentation in 6 hrs compared to 18 hrs for C8 ceramide.


References

1: N. Karasavvas et al. Eur. J. Biochem. 1996 236 729

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), DMF (~20 mg/ml), PBS (pH 7.2) (~50 µg/ml), and water (<50 µg/ml) at 25° C.
Storage :
Store at -20° C
Boiling Point :
~532.9° C at 760 mmHg (Predicted)
Density :
~0.90 g/cm3 (Predicted)
Refractive Index :
n20D 1.48 (Predicted)
pK Values :
pKa: 13.78 (Predicted), pKb: 8.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16759361
MDL Number :
MFCD01632747
SMILES :
CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)NCCCCCCCC)O

Download SDS (MSDS)

Certificate of Analysis

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