C8 Ceramine, D-erythro is an analog of ceramide in which the amide is substituted with an amine. This substitution renders it inert to ceramidases. It is highly effective at induction of apoptosis in U937 cells. Ceramine induces peak DNA fragmentation in 6 hrs compared to 18 hrs for C8 ceramide.
1: N. Karasavvas et al. Eur. J. Biochem. 1996 236 729
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), DMF (~20 mg/ml), PBS (pH 7.2) (~50 µg/ml), and water (<50 µg/ml) at 25° C.
Store at -20° C
~532.9° C at 760 mmHg (Predicted)
~0.90 g/cm3 (Predicted)
n20D 1.48 (Predicted)
pKa: 13.78 (Predicted), pKb: 8.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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