C75 (racemic)An inhibitor of FAS

C75 (racemic) (CAS 191282-48-1)

C75 (racemic) | CAS 191282-48-1 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_19, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3-b1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202511, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 105ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid; (±)-C75
Application: An inhibitor of FAS
CAS Number: 191282-48-1
Purity: >98%
Molecular Weight: 254.32
Molecular Formula: C14H22O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

C75 is an inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of fatty acid synthase. Downregulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant antitumor activity in human breast cancer cells. Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to a dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.


References

1. Pizer, E.S., et al. 1998. Cancer Res. 58: 4611-4615. PMID: 9788612
2. Kuhajda, F.P., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 3450-3454. PMID: 10716717
3. Loftus, T.M., et al. 2000. Science. 288: 2379-2381. PMID: 10875926
4. Pizer, E.S., et al. 2000. Cancer Res. 60: 213-218. PMID: 10667561
5. Gabrielson, E.W., et al. 2001. Clin. Cancer Res. 7: 153-157. PMID: 11205903
6. Li, J.N., et al. 2001. Cancer Res. 61: 1493-1439. PMID: 11245456
7. Wang, X., et al. 2001. Biochem Biophys Res Commun. 288: 1200-1206. PMID: 11700039
8. Clegg, D.J., et al. 2002. Diabetes. 51: 3196-3201. PMID: 12401710
9. Kim, E.K., et al. 2002. Am. J. Physiol. Endocrinol. Metab. 283: 867-879. PMID: 12376313
10. Kumar, M.V., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 1921-1925. PMID: 11854492
11. Shimokawa, T., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 66-71. PMID: 11756683
12 Thupari, J.N., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 9498-9502. PMID: 12060712

Physical State :
Solid
Solubility :
Soluble in methanol, DMSO (10 mg/ml), ethanol (30 mg/ml), DMF (30 mg/ml), and PBS (pH 7.2) (≥ 0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
142.14° C (Predicted)
Boiling Point :
~432.1° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.49 (Predicted)
IC50 :
Fatty acid synthase: IC50 = 15.53 µM (rat)
pK Values :
pKa: 3.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9881506
MDL Number :
MFCD03265452
SMILES :
CCCCCCCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

C75 (racemic)  Product Citations

See how others have used C75 (racemic). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27270654  Goswami, S. et al. 2016. Oncotarget. 7: 58953-58974.

PMID: # 26549524  Thorsteinsdottir, UA. et al. 2016. Phytother Res. 30: 97-104.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

PMID: # 31708446  Cell Metab.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 65ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Use it routinely in our lab and works well Use it routinely in our lab and works well.
Date published: 2015-06-17
  • y_2019, m_11, d_19, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3-b1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202511, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 48ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.