C6 Ceramide-13C2,d2A ceramide analog that stimulates protein phosphatase 2A and activates MAP kinase

C6 Ceramide-13C2,d2

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Application: A ceramide analog that stimulates protein phosphatase 2A and activates MAP kinase
Purity: 98%
Molecular Weight: 401.63
Molecular Formula: C2213C2H45D2NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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C6 Ceramide-13C2,d2 is a biologically active, cell permeable, but nonphysiological ceramide analog. Stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway.


References

1. Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268: 15523-15530. PMID: 8393446
2. Raines, M.A., et al. 1993. J. Biol. Chem. 268: 14572-14575. PMID: 7686898
3. Jarvis, W.D., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 73-77. PMID: 8278410

Physical State :
Solid
Solubility :
Chloroform and Methanol
Storage :
Store at -20° C
Melting Point :
69-72
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46780961
SMILES :
[2H]C([2H])(O)[13C@H](NC(=O)CCCCC)[C@H](O)\\C=C\\CCCCCCCCCCCCC

Download SDS (MSDS)

Certificate of Analysis

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