C2 Ceramide is a ceramide shown to be a potent modulator of proliferation and differentiation, used as a tool for studying the complex signaling associated with the ceramides. N-Acetyl-D-sphingosine and other ceramides are shown to activate a cystolic serine/threonine protein phosphatase. The main ceramide-activated protein phosphatase was isolated and identified as trimeric and dimeric PP2A. The sphingomyelin pathway, which generates ceramides as second messengers, is thought to mediate apoptosis in response to TNF-α through the stress-activated protein kinase (SAPK/JNK) signaling system. Potential activator of ERK 2, PP1, and PP2.
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See how others have used C2 Ceramide. Click on the entry to view the PubMed entry .
PMID: # 29723246 Grundy, M. et al. 2018. PLoS ONE. 13: e0196805.
PMID: # 29272817 Nishiyama, K.|Fujita, T.|Fujimoto, Y.|Nakajima, H.|Takeuchi, T.|Azuma, YT.| et al. 2018. Int. Immunopharmacol. 55: 205-215.
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