C2 CeramideA ser/thr protein phosphatase activator

C2 Ceramide (CAS 3102-57-6)

C2 Ceramide | CAS 3102-57-6 is rated 5.0 out of 5 by 1.
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Synonym: Acetyl ceramide; N-Acetyl-D-erythro-sphingosine; N-Acetyl-D-sphingosine
Application: A ser/thr protein phosphatase activator
CAS Number: 3102-57-6
Purity: ≥98%
Molecular Weight: 341.53
Molecular Formula: C20H39NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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C2 Ceramide is a ceramide shown to be a potent modulator of proliferation and differentiation, used as a tool for studying the complex signaling associated with the ceramides. N-Acetyl-D-sphingosine and other ceramides are shown to activate a cystolic serine/threonine protein phosphatase. The main ceramide-activated protein phosphatase was isolated and identified as trimeric and dimeric PP2A. The sphingomyelin pathway, which generates ceramides as second messengers, is thought to mediate apoptosis in response to TNF-α through the stress-activated protein kinase (SAPK/JNK) signaling system. Potential activator of ERK 2, PP1, and PP2.


References

1. Dobrowsky, R.T., et al. 1992. J. Biol. Chem. 267: 5048-5051. PMID: 1312082
2. Nakamura, Y., et al. 1996. J. Immunol. 156: 256-262. PMID: 8598470
3. Verheij, M., et al. 1996. Nature. 380: 75-79. PMID: 8598911
4. Galadari, S., et al. 1998. Biochemistry. 37: 11232-11238. PMID: 9698369
5. Radin, N.S., 2003. Biochem. J. 371: 243-256. PMID: 12558497

Physical State :
Solid
Solubility :
Soluble in 100% ethanol (>25 mg/ml), DMSO (>50 mg/ml), methanol (5 mg/ml), chloroform (~10 mg/ml), dichloromethane, and water (partly miscible).
Storage :
Store at -20° C
Melting Point :
93-96° C
Boiling Point :
532.36° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.48 (Predicted)
IC50 :
MCF7: IC50 = 45.41 µM (human); NHDF: IC50 = 66.5 µM (human); CCRF-CEM: IC50 = 31.6 µM (human); MDA-MB-231 : IC50 = 35.37 µM (human); NCI-H358: EC5050 = 19.6 µM (human); HCT-116: EC5050 = 24.5 µM (human); K562 : EC5050 = 35.1 µM (human)
pK Values :
pKa: 13.50 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6604750
MDL Number :
MFCD00153903
Beilstein Registry :
1728870
SMILES :
CCCCCCCCCCCCC/C=C\\[C@H]([C@H](CO)NC(=O)C)O

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C2 Ceramide  Product Citations

See how others have used C2 Ceramide. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 29723246  Grundy, M. et al. 2018. PLoS ONE. 13: e0196805.

PMID: # 29272817  Nishiyama, K.|Fujita, T.|Fujimoto, Y.|Nakajima, H.|Takeuchi, T.|Azuma, YT.| et al. 2018. Int. Immunopharmacol. 55: 205-215.

PMID: # 28231980  Kim, JY. et al. 2017. J Endod. 43: 417-424.

PMID: # 24530966  Arias, ER. et al. 2014. Neuropharmacology. 81: 206-14.

PMID: # 12529324  Paitel, E. et al. 2003. J. Biol. Chem. 278: 10061-10066.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from C2 Ceramide C2 Ceramide, a ser/thr protein phosphatase activator, can be used as a stimulator for apoptosis (PubMed ID 12529324). -SCBT QC
Date published: 2015-06-02
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