C16 Ceramide (N-Palmitoylsphingosine, D-erythro)An endogenous ceramide

C16 Ceramide (N-Palmitoylsphingosine, D-erythro) (CAS 24696-26-2)

C16 Ceramide (N-Palmitoylsphingosine, D-erythro) | CAS 24696-26-2 is rated 5.0 out of 5 by 2.
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Synonym: N-Palmitoyl-D-erythro-sphingosine;N-Hexadecanoyl-D-erythro-sphingosine;N-Palmitoyl ceramide
Application: An endogenous ceramide
CAS Number: 24696-26-2
Purity: 98%
Molecular Weight: 537.9
Molecular Formula: C34H67NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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C16 ceramide is an abundant, hydrophobic molecular species of endogenous ceramide. It has been found to stimulate ceramide-activated protein kinase, inducing phosphorylation epidermal growth factor. It has also been found to activate NF-κB and PKCζ3.


References

1. Shoyama, Y., et al. 1978. J. Lipid Res. 19: 250-259. PMID: 632688
2. Mathias, S., et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 10009-10013. PMID: 1946418
3. Dobrowsky, R.T. and Hannun, Y.A. 1992. J. Biol. Chem. 267: 5048-5051. PMID: 1312082
4. Lozano, J., et al. 1994. J. Biol. Chem. 269: 19200-19202. PMID: 8034680
5. Müller, G., et al. 1995. EMBO J. 14: 1961-1969. PMID: 7744003

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml, warm), DMF (~0.15 mg/ml), and Chloroform. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
98-99° C
Boiling Point :
675.4° C at 760 mmHg (Predicted)
Density :
0.92 g/cm3
Refractive Index :
n20D 1.48
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5283564
MDL Number :
MFCD00056205
SMILES :
CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H](/C=C/CCCCCCCCCCCCC)O

Download SDS (MSDS)

Certificate of Analysis

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C16 Ceramide (N-Palmitoylsphingosine, D-erythro)  Product Citations

See how others have used C16 Ceramide (N-Palmitoylsphingosine, D-erythro). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30952607  Wu, J.|Ma, S.|Sandhoff, R.|Ming, Y.|Hotz-Wagenblatt, A.|Timmerman, V.|Bonello-Palot, N.|Schlotter-Weigel, B.|Auer-Grumbach, M.|Seeman, P.|Löscher, WN.|Reindl, M.|Weiss, F.|Mah, E.|Weisshaar, N.|Madi, A.|Mohr, K.|Schlimbach, T.|Velasco Cárdenas, RM.|Koeppel, J.|Grünschläger, F.|Müller, L.|Baumeister, M.|Brügger, B.|Schmitt, M.|Wabnitz, G.|Samstag, Y.|Cui, G.| et al. 2019. Immunity. 50: 1218-1231.e5.

PMID: # 25436917  Gao, H. et al. 2015. Archives of biochemistry and biophysics. 565: 76-88.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from All good! Molecule shipped quickly and arrived in good shape. Chemical was used for different assays and as a reference. All Good!
Date published: 2018-08-15
Rated 5 out of 5 by from Stiban Stiban, J. et al. (PubMed 25462172) found that very long chain ceramides interfere with C16 Ceramide-induced channel formation. -SCBT Publication Review
Date published: 2015-01-29
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