BzATP triethylammonium saltCAS: 112898-15-4
MF: C24H24N5O15P3•3(C6H15N)
MW: 1018.97
A P2X7 receptor agonist.

BzATP triethylammonium salt (CAS 112898-15-4)

BzATP triethylammonium salt | CAS 112898-15-4 is rated 5.0 out of 5 by 1.
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Synonym: benzoylbenzoyl-ATP; Bz-ATP
Application: A P2X7 receptor agonist
CAS Number: 112898-15-4
Purity: >95%
Molecular Weight: 1018.97
Molecular Formula: C24H24N5O15P33(C6H15N)
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

BzATP triethylammonium salt is a prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.


References

Williams and Coleman (1982) Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate. J.Biol.Chem. 257 2834. Zhong et al (1998) Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br.J.Pharmacol. 125 771. Michel et al (2001) Serum constituents can effect 2'- & 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X7 receptors. Br.J.Pharmacol. 132 1501.

Physical State :
Solid
Solubility :
Soluble in water
Storage :
Desiccate at -20° C
IC50 :
P2X7 receptor : IC50 = 0.7 µM (HEK 293 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71308559
SMILES :
CCN(CC)CC.C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C(=O)O[C@@H]3[C@H](O[C@H]([C@@H]3O)N4C=NC5=C4N=CN=C5N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O

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Certificate of Analysis

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BzATP triethylammonium salt  Product Citations

See how others have used BzATP triethylammonium salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28669743  Caglayan, B. et al. 2017. Exp. Neurol. 296: 23-31.

PMID: # 22644907  Gehring, MP. et al. 2012. Purinergic signalling. 8: 729-39.

Citations 1 to 2 of 2 total

Is this product available as a pre-dissolved liquid?

Asked by: SCM4
BzATP triethylammonium salt is supplied as a solid, but may be ordered as a Special Order as a pre-dissolved product. Contact us at specialorders at scbt.com for more information.
Answered by: Tech Service 11
Date published: 2017-03-02
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Rated 5 out of 5 by from Hu Hu, et al. (PubMed ID 26354875) used BzATP to induce IL-1 release and triggered reactive oxygen species (ROS) production in rat peritoneal macrophages. -SCBT Publication Review
Date published: 2015-03-31
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