BYK204165A potent and selective PARP-1 inhibitior

BYK204165 (CAS 1104546-89-5)

BYK204165 | CAS 1104546-89-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_15, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_214642, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 73ms
  • REVIEWS, PRODUCT
Synonym: PARP Inhibitor XIV; 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
Application: A potent and selective PARP-1 inhibitior
CAS Number: 1104546-89-5
Purity: ≥98%
Molecular Weight: 252.27
Molecular Formula: C15H12N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

BYK204165, also known as PARP Inhibitor XIV, is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear enzyme involved in the regulation of various cell processes such as differentiation, proliferation, and tumor transformation. It is also involved in the regulation of the molecular events involved in the recovery of cell from DNA damage. BYK204165's potency is similar or higher than most current standard PARP-1 inhibitors (just slightly lower than PJ34), and it is 100-fold selective for PARP-1 over PARP-2.


References

1. Eltze, T., et al. 2008. Mol. Pharmacol. 74: 1587-1598. PMID: 18809672

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
25113764
SMILES :
CN1C=CC=C1/C=C\\2/C3=CC=CC=C3C(=O)NC2=O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

BYK204165  Product Citations

See how others have used BYK204165. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30387075  Prado Spalm, FH. et al. 2018. Mol. Neurobiol.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 68ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Eltze et al Eltze et al. (PubMed ID 18809672) found that BYK204165 inactivated cell-free recombinant human PARP-1 and did so in a more potent and selective manner than other PARP-1 inhibitors. -SCBT Publication Review
Date published: 2015-01-03
  • y_2019, m_9, d_15, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_214642, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 66ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.