BW A868CA hydantoin compound structurally related to the DP agonist BW245C

BW A868C (CAS 118675-50-6)

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Synonym: 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid
Application: A hydantoin compound structurally related to the DP agonist BW245C
CAS Number: 118675-50-6
Purity: >98%
Molecular Weight: 459.58
Molecular Formula: C25H37N3O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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BW A868C is a hydantoin compound structurally related to the DP agonist BW245C. BW A868C antagonizes prosaglandin D2 and BW245C-induced activation of human platelet adenylate cyclase. Has been shown to antagonize accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. Shows virtually no effect on human TP, IP, EP1, EP2, and FP receptors. Ki is approximately 1.7 nM.


References

1 Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc , Chem Commun (1979). 2 Trist, D.G., Collins, B.A., Wood, J., et al. The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. Br J Pharmacol 96 301-306 (1989). 3 Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Exp Eye Res 62 491-498 (1996). 4 Giles, H., Leff, P., Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol 96 291-300 (1989).

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (0.25 mg/ml at 25° C), DMSO (~20 mg/ml), DMF (~20 mg/ml), PBS (pH 7.2) (~0.25 mg/ml), and ethanol.
Storage :
Store at -20° C
Boiling Point :
78° C (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
122021
MDL Number :
MFCD00877696
SMILES :
C1CCC(CC1)C(CNN2C(C(=O)N(C2=O)CC3=CC=CC=C3)CCCCCCC(=O)O)O

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Certificate of Analysis

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