Date published: 2025-10-21

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Butyl isocyanide (CAS 2769-64-4)

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Alternate Names:
1-Butylisonitrile; Butyl isonitrile; n-Butyl isocyanide; n-Butyl isonitrile
CAS Number:
2769-64-4
Molecular Weight:
83.13
Molecular Formula:
C5H9N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Butyl isocyanide is an organic compound characterized by its volatile nature and distinct odor. This colorless liquid is utilized in the synthesis of organic compounds, serving as a valuable reagent in organic chemistry. In scientific research, Butyl isocyanide has demonstrated its efficacy in various applications. It has proven instrumental in synthesizing organic compounds, notably isocyanide-containing peptides, which play a vital role in exploring protein folding and structure. Furthermore, Butyl isocyanide has been employed in the creation of polymers, including polyurethanes and polyureas. Acting as a nucleophilic reagent in organic chemistry, Butyl isocyanide participates in reactions with other organic compounds, such as alcohols and amines, leading to the formation of novel compounds. Notably, it can react with alcohols to generate isocyanates, which subsequently engage in reactions with other organic compounds, culminating in polymer formation.


Butyl isocyanide (CAS 2769-64-4) References

  1. Spectral differences between the alpha and beta heme groups within human deoxyhemoglobin.  |  Olson, JS. 1976. Proc Natl Acad Sci U S A. 73: 1140-4. PMID: 1063394
  2. Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam.  |  Lee, DS., et al. 2001. Biochemistry. 40: 2669-77. PMID: 11258878
  3. Nuclear Magnetic Resonance Shift Reagents: Abnormal C Shifts Produced by Complexation of Lanthanide Chelates with Saturated Amines and n-Butyl Isocyanide.  |  Marzin, C., et al. 1973. Proc Natl Acad Sci U S A. 70: 562-3. PMID: 16592062
  4. Measurement of ethylene binding in plant tissue.  |  Sisler, EC. 1979. Plant Physiol. 64: 538-42. PMID: 16661005
  5. Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide.  |  Derbyshire, ER. and Marletta, MA. 2007. J Biol Chem. 282: 35741-8. PMID: 17916555
  6. n-Butyl isocyanide oxidation at the [NiFe4S4OH(x)] cluster of CO dehydrogenase.  |  Jeoung, JH. and Dobbek, H. 2012. J Biol Inorg Chem. 17: 167-73. PMID: 21904889
  7. Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles.  |  Shaw, AY., et al. 2012. Tetrahedron Lett. 53: 2592-2594. PMID: 22544981
  8. Ligand recombination to the alpha and beta subunits of human hemoglobin.  |  Olson, JS., et al. 1987. J Biol Chem. 262: 12930-8. PMID: 3654596
  9. Geminate recombination of n-butyl isocyanide to myoglobin.  |  Sommer, JH., et al. 1985. Biochemistry. 24: 7380-8. PMID: 4084587
  10. The reaction of n-butyl isocyanide with human hemoglobin. 3. Temperature jump relaxation kinetics.  |  Cole, FX. and Gibson, QH. 1973. J Biol Chem. 248: 4998-5004. PMID: 4736888
  11. The reaction of n-butyl isocyanide with human hemoglobin. I. Determination of the kinetic parameters involved in the last step in ligand binding.  |  Olson, JS. and Gibson, QH. 1971. J Biol Chem. 246: 5241-53. PMID: 5106729
  12. Organic phosphates and the reaction of N-butyl isocyanide with human hemoglobin.  |  Olson, JS. and Gibson, QH. 1970. Biochem Biophys Res Commun. 41: 421-6. PMID: 5518171

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Butyl isocyanide, 1 g

sc-257203
1 g
$97.00