Busulfan is an antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.
1. Iwamoto, T. et al. 2004. Cancer Sci. 95(5): 454-458. PMID: 15132775
2. Morales-Ramírez, P. et al. 2006. Arch. Med. Res. 37(3): 316-321. PMID: 16513478
3. Probin, V. et al. 2007. Free Radic. Biol. Med. 42(12): 1858-1865. PMID: 17512465
Soluble in acetone, 100% ethanol or DMSO; insoluble in water.
Store at -20° C
114-117° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Hi, can you please send us a price offer for busulfan? We are from the Institute of Cellular Biology and Pathology "N Simionescu", Bucharest, Romania.
Ana Vacaru, PhD
Asked by: AnaV
Thank you for your message. Our Customer Service department will contact
you asap with the lead time and price quotation for this product.
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Answered by: Technical Support Europe
Date published: 2018-07-03
What is the storage once the compound is in solution in DMSO?
Asked by: two2igm05
Thank you for your question. This product has standard long term storage, aliquot into single size uses (avoid freeze/thaw cycles) at -80℃, will last at least 6 months. You can also store in -20°C in single aliquots for a shorter period of time.
Answered by: Technical Support
Date published: 2017-01-11
How should Busulfan be stored once it has been solubilized in DMSO?
Asked by: ChemSynth123
Thank you for your question. It is recommended to use solutions the same day they are made. A DMSO solution containing sc-204658 should be aliquoted into single size uses and stored at -80℃. The aliquots should be stable for at least 6 months when stored at -80ºC. The aliquots can be stored at -20°C for a shorter period of time. Multiple freeze/thaw cycles should be avoided.
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