BusulfanA DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins

Busulfan (CAS 55-98-1)

Busulfan | CAS 55-98-1 is rated 5.0 out of 5 by 1.
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Application: A DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins
CAS Number: 55-98-1
Purity: ≥98%
Molecular Weight: 246.3
Molecular Formula: C6H14O6S2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Busulfan is an antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.


References

1. Iwamoto, T. et al. 2004. Cancer Sci. 95(5): 454-458. PMID: 15132775

2. Morales-Ramírez, P. et al. 2006. Arch. Med. Res. 37(3): 316-321. PMID: 16513478

3. Probin, V. et al. 2007. Free Radic. Biol. Med. 42(12): 1858-1865. PMID: 17512465

Physical State :
Solid
Solubility :
Soluble in acetone, 100% ethanol or DMSO; insoluble in water.
Storage :
Store at -20° C
Melting Point :
114-117° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
EK1750000
PubChem CID :
2478
Merck Index :
14: 1505
MDL Number :
MFCD00007562
EC Number :
200-250-2
SMILES :
CS(=O)(=O)OCCCCOS(=O)(=O)C

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Certificate of Analysis

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Hi, can you please send us a price offer for busulfan? We are from the Institute of Cellular Biology and Pathology "N Simionescu", Bucharest, Romania. Thank you. Regards, Ana Vacaru, PhD

Asked by: AnaV
Thank you for your message. Our Customer Service department will contact you asap with the lead time and price quotation for this product. Most of our products are currently on stock in our European Support Office and we ship these over night, however specific delivery time can depend by destination, amount and current availability.
Answered by: Technical Support Europe
Date published: 2018-07-03

What is the storage once the compound is in solution in DMSO?

Asked by: two2igm05
Thank you for your question. This product has standard long term storage, aliquot into single size uses (avoid freeze/thaw cycles) at -80℃, will last at least 6 months. You can also store in -20°C in single aliquots for a shorter period of time.
Answered by: Technical Support
Date published: 2017-01-11

How should Busulfan be stored once it has been solubilized in DMSO?

Asked by: ChemSynth123
Thank you for your question. It is recommended to use solutions the same day they are made. A DMSO solution containing sc-204658 should be aliquoted into single size uses and stored at -80℃. The aliquots should be stable for at least 6 months when stored at -80ºC. The aliquots can be stored at -20°C for a shorter period of time. Multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2016-12-14
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Rated 5 out of 5 by from Jung Jung, SW. et al. (PubMed 26199556) used the DNA alkylating agent Busulfan to induce dysfunction of the male reproductive system. -SCBT Publication Review
Date published: 2015-04-20
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