Bupivacaine Free BaseLocal anesthetic which binds to the intracellular portion of sodium channels and blocks sodium influx into the nerve cells

Bupivacaine Free Base (CAS 38396-39-3)

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Synonym: Marcaine; Sensorcaine; DL-Bupivacaine
Application: Local anesthetic which binds to the intracellular portion of sodium channels and blocks sodium influx into the nerve cells
CAS Number: 38396-39-3
Molecular Weight: 288.43
Molecular Formula: C18H28N2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bupivacaine free base is a local anesthetic which binds to the intracellular portion of sodium channels and blocks sodium influx into the nerve cells, which prevents depolarization. Bupivacaine Free Base is an inhibitor of Sodium Channel Protein.


References

1. Coskuner, I., et al. 2007. Eur J Anaesthesiol. 24: 535-540. PMID: 17241499
2. Lee, S.J., et al. 2008. Anesth. Analg. 107: 824-827. PMID: 18713891
3. Kucukguclu, S., et al. 2008. Eur J Anaesthesiol. 25: 307-313. PMID: 17888192

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, ethanol, chloroform (slightly ), and acetone (slightly ).
Storage :
Store at room temperature
Melting Point :
107-110° C
Boiling Point :
~423.4° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
CYP2D6: IC50 = 400 nM (human); Displacement of [3H]-BTX-B: IC50 = 5.37 µM; Na+ CP type Iα, Na+ CP type IIα, Na+ CP type IIIα: IC50 = 5.4 µM (human); HERG: IC50 = 22 µM (human); Expression of ERG Y652A mutant channel : IC50 = 95 µM (human)
pK Values :
pKb: 8.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2474
Merck Index :
14: 1495
MDL Number :
MFCD00243007
EC Number :
253-911-2
SMILES :
CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C

Download SDS (MSDS)

Certificate of Analysis

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Can you provide sterile pharma grade bupivacaine (free base)?

Asked by: Or Cohen
No, we do not provide pharmaceutical grade chemicals. Our chemicals are for research use only.
Answered by: Technical Support
Date published: 2018-12-17

The more I buy do it becomes cheaper like if I buy 100 grams of free base bupivacaine how much it will cost me

Asked by: Team player
For bulk order pricing please contact our Special Orders Department. Please call us toll-free at (800) 457-3801 option 2, or email specialorders@scbt.com.
Answered by: Technical Support
Date published: 2018-11-19
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