BufalinInducer of apoptosis in human HL-60 and U-937 cell lines

Bufalin (CAS 465-21-4)

Bufalin | CAS 465-21-4 is rated 5.0 out of 5 by 1.
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Synonym: (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide; 5β,20(22)-Bufadienolide-3β,14-diol
Application: Inducer of apoptosis in human HL-60 and U-937 cell lines
CAS Number: 465-21-4
Purity: ≥98%
Molecular Weight: 386.52
Molecular Formula: C24H34O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bufalin, is a cardiotonic steroid originally isolated from the Chinese toad venom. Experiments have shown Bufalin to have demonstrated apoptotic and cell differentiation inducing properties in U-937 (sc-2239) cells through activation of AP-1 via a mitogen-activated protein kinase cascade. In conjunction, research has shown Bufalin to be an inhibitor of Na+/K+-ATPase which causes downregulation of mRNA transcripts encoding several isoforms of 14-3-3 gene. 14-3-3 proteins are multifunctional regulatory proteins, and the reduction in the abundance of various isoforms has been shown to have profound effects on cell function. Other studies have noted an enhancement of retinoic acid-induced differentiation of HL-60 (sc-2209) cells in primary culture.


References

1. Yamada, K., et al. 1998. Leuk. Res. 22: 589-595. PMID: 9680108
2. Watabe, M., et al. 1998. Oncogene. 16: 779-787. PMID: 9488042
3. Kawazoe, N., et al. 1999. J. Biochem. 126: 278-286. PMID: 10423518
4. McGowan, M.H., et al. 1999. J. Pharmacol. Exp. Ther. 289: 1559-1563. PMID: 10336553

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in chloroform (5 mg/ml), DMSO (25 mg/ml), and 100% ethanol (25 mg/ml,warm).
Storage :
Desiccate at -20° C
Melting Point :
219.93° C (Predicted)
Boiling Point :
~556.6° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EI2962500
Transport :
UN 3462, Class 6.1, Packing group II
PubChem CID :
10061
Merck Index :
14: 1471
MDL Number :
MFCD00056525
SMILES :
C[C@]12CC[C@@H](C[C@H]1CCC3C2CC[C@]4([C@@]3(CC[C@@H]4C5=COC(=O)C=C5)O)C)O

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Bufalin  Product Citations

See how others have used Bufalin. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 30714337  Zhang, YY.|Liu, MY.|Liu, Z.|Zhao, JK.|Zhao, YG.|He, L.|Li, W.|Zhang, JQ.| et al. 2019. CNS Neurosci Ther. 25: 714-733.

PMID: # 30423406  Song, X. et al. 2018. Cancer Lett. 442: 310-319.

PMID: # 29174112  Oliveira, RS.|Leal, AP.|Ogata, B.|Moreira de Almeida, CG.|Dos Santos, DS.|Lorentz, LH.|Moreira, CM.|de Castro Figueiredo Bordon, K.|Arantes, EC.|Dos Santos, TG.|Dal Belo, CA.|Vinadé, L.| et al. 2018. Neurotoxicology. 65: 264-271.

PMID: # 26431029  Song, X. et al. 2015. PloS one. 10: e0140011.

Citations 1 to 4 of 4 total

is bufalin available right now?

Asked by: ning zhang
Thank you for your question. Please contact our Customer Care Department to inquire about current product availability. Please call us directly by phone at (800) 457-3801 option 1, or email customercare@scbt.com, or use our Live Chat on our website, www.scbt.com.
Answered by: Technical Support
Date published: 2017-01-03
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Rated 5 out of 5 by from Zhao Zhao, et al. (PubMed ID 26133118) found that bufalin suppresses TGF- -induced EMT and migration. It was done by downregulating T RI and T RII in A549 cells. -SCBT Publication Review
Date published: 2015-05-17
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