BTSA potent inhibitor of Ca2+-stimulated myosin S1 ATPase

BTS (CAS 1576-37-0)

BTS | CAS 1576-37-0 is rated 5.0 out of 5 by 1.
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Synonym: N-Benzyl-4-methylbenzenesulfonamide
Application: A potent inhibitor of Ca2+-stimulated myosin S1 ATPase
CAS Number: 1576-37-0
Purity: >98%
Molecular Weight: 261.3
Molecular Formula: C14H15NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. It also weakens myosin's interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.


References

Cheung, A., et al. 2002. Nat. Cell Biol. 4, 83.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (70 mM), chloroform, dichloromethane, and ethyl acetate.
Storage :
Store at 4° C
Melting Point :
115° C
Boiling Point :
419.08° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Ca2+-stimulated myosin S1 ATPase: IC50 = ~ 5 µM
pK Values :
pKa: 11.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
XT5490000
PubChem CID :
95801
MDL Number :
MFCD00159328
Beilstein Registry :
2217277
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=CC=C2

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Certificate of Analysis

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BTS  Product Citations

See how others have used BTS. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27037492  2016. Eur. J. Neurosci. 43: 1623-35.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Sylow et al Sylow et al. (PubMed ID 25416624) used BTS to inhibit ATPase and block cross-bridge formation in order to evaluate Rac1 in contraction-stimulated glucose transport during conditions without mechanical load in skeletal muscle. -SCBT Publication Review
Date published: 2015-05-13
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