BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. It also weakens myosin's interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
Cheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
Soluble in DMSO (100 mM), ethanol (70 mM), chloroform, dichloromethane, and ethyl acetate.
Store at 4° C
419.08° C at 760 mmHg (Predicted)
1.20 g/cm3 (Predicted)
n20D 1.59 (Predicted)
Ca2+-stimulated myosin S1 ATPase: IC50 = ~ 5 µM
pKa: 11.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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BTS Product Citations
See how others have used BTS. Click on the entry to view the PubMed entry
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Sylow et alSylow et al. (PubMed ID 25416624) used BTS to inhibit ATPase and block cross-bridge formation in order to evaluate Rac1 in contraction-stimulated glucose transport during conditions without mechanical load in skeletal muscle. -SCBT Publication Review
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