BTA-1 MF: C14H12N2S
MW: 240.3
A fluorescent Thioflavin-T derivative that shows great affinity for amyloid deposits.

BTA-1

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Alternate Names: 2-(4′-Methylaminophenyl)benzothiazole
Application: BTA-1 is a fluorescent Thioflavin-T derivative that shows great affinity for amyloid deposits
Molecular Weight: 240.3
Molecular Formula: C14H12N2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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BTA-1 is a fluorescent Thioflavin-T derivative that exhibits greater affinity than Thioflavin-T and shows great affinity for amyloid deposits. BTA-1 may cross the blood brain barrier.


References

Klunk, W.E., et al. 2003. J. Neurosci. 23, 2086. Mathis, C.A., et al. 2002. Bioorg. Med. Chem. Lett. 12, 295. Klunk, W.E., et al. 2001. Life Sci. 69, 1471.

Physical State :
Solid
Solubility :
Soluble in DMSO (~10 mg/mL).
Storage :
Store at 4° C
Melting Point :
153.83° C (Predicted)
Boiling Point :
415.54° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
Ki Data :
Aβ 40: Ki= 11 nM; binding affinity to Beta amyloid aggregates : Ki= 1.28 nM
Fluoresence :
λex ~750 nm, λem ~380-480 nm
pK Values :
pKb: 2.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD04974146
SMILES :
CNC1=CC=C(C=C1)C2=NC3=CC=CC=C3S2

Download SDS (MSDS)

Certificate of Analysis

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