Bryostatin 2A macrocyclic lactone and antagonist of phorbol ester action

Bryostatin 2 (CAS 87745-28-6)

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Application: A macrocyclic lactone and antagonist of phorbol ester action
CAS Number: 87745-28-6
Molecular Weight: 863.01
Molecular Formula: C45H66O16
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bryostatin 2 is a macrocyclic lactone with anti-tumor properties and activator of PKC (protein kinase C) which inhibit the growth of A549 cells. Bryostatin 2 has been documented to compete with phorbol ester binding to PKC at a Ki= 3.4 nM and antagonizes phorbol esteraction. The compound has been observed to induce variable arachidonic acid release. Bryostatin 2 has demonstrated to synergistically, with recombinant B cell stimulatory factor-1, cause differentiation in resting lymph node T cells. Bryostatin 2 also exhibits growth inhibitory activity against several human cancer cell lines.


References

1. Dell'Aquila, M.L., et al. 1988. Cancer Res. 48: 3702-3708. PMID: 3132318
2. Trenn, G., et al. 1988. J. Immunol. 140: 433-439. PMID: 3257237
3. Dale, I.L., et al. 1989. Cancer Res. 49: 3242-3245. PMID: 2720677

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~957.2° C at 760 mmHg (Predicted)
Density :
1.28 g/mL (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Ki Data :
compete with phorbol ester binding to PKC: Ki= 3.4 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6438131
MDL Number :
MFCD00676567
SMILES :
CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/C[C@@H](O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)O)O)[C@@H](C)O

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Certificate of Analysis

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Bryostatin 2  Product Citations

See how others have used Bryostatin 2. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30535430  2019. Int. J. Oncol. 54: 515-526.

Citations 1 to 1 of 1 total
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