Bryostatin 2 is a macrocyclic lactone with anti-tumor properties and activator of PKC (protein kinase C) which inhibit the growth of A549 cells. Bryostatin 2 has been documented to compete with phorbol ester binding to PKC at a Ki= 3.4 nM and antagonizes phorbol esteraction. The compound has been observed to induce variable arachidonic acid release. Bryostatin 2 has demonstrated to synergistically, with recombinant B cell stimulatory factor-1, cause differentiation in resting lymph node T cells. Bryostatin 2 also exhibits growth inhibitory activity against several human cancer cell lines.
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