Bryostatin 1A macrolactone marine natural product that binds to and modulates PKC

Bryostatin 1 (CAS 83314-01-6)

Bryostatin 1 | CAS 83314-01-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_18, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201407, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 173ms
  • REVIEWS, PRODUCT
Application: A macrolactone marine natural product that binds to and modulates PKC
CAS Number: 83314-01-6
Purity: ≥98%
Molecular Weight: 905.03
Molecular Formula: C47H68O17
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Bryostatin 1 is structurally unique macrolactone marine natural product that binds to and modulates PKC (protein kinase C) activity at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces only a subset of the responses to PMA and blocks those which it does not induce. It is markedly more potent than PMA for translocating PKCδ and -ε. Animal tests have shown bryostatin 1 may alleviate brain damage after a stroke. Bryostatin 1 administered with lactacystin has displayed synergistically induced apoptosis in human leukemia cells.


References

1. Hennings, H., et al. 1987. Carcinogenesis. 8: 1343-1346. PMID: 3621472
2. Szallasi, Z., et al. 1994. J. Biol. Chem. 269: 2118-2124. PMID: 8294465
3. Song, X., et al. 1999. J. Biol. Chem. 274: 1677-1682. PMID: 9880547
4. Gschwend, J.E., et al. 2000. Mol. Pharmacol. 57: 1224-1234. PMID: 10825394
5. Vrana, J.A. and Grant, S. 2001. Blood. 97: 2105-2114. PMID: 11264178
6. Sun, M.K. and Alkon, D.L. 2005. Eur. J. Pharmacol. 512: 43-51. PMID: 15814089
7. Kuzirian, A.M., et al. 2006. Biol. Bull. 210: 201-214. PMID: 16801495
8. El-Rayes, B.F., et al. 2006. Clin. Cancer Res. 12: 7059-7062. PMID: 17145828
9. Sun, M.K., et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 14676-14680. PMID: 19667190

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Refractive Index :
n20D 1.57 (Predicted)
Ki Data :
protein kinase C: Ki= 1.35 nM
pK Values :
pKa: 11.1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EH9455000
PubChem CID :
6473739
Merck Index :
14: 1457
MDL Number :
MFCD00893832
SMILES :
CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/CC(O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Bryostatin 1  Product Citations

See how others have used Bryostatin 1. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30008723  Desimio, MG. et al. 2018. Front Immunol. 9: 1514.

PMID: # 28638377  Huang, H. et al. 2017. Front Microbiol. 8: 1035.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 66ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Sun et al Sun et al. (PubMed ID 19667190) found that bryostatin 1 prevented apoptotic cell death induced by ischemia/hypoxia. -SCBT Publication Review
Date published: 2015-06-24
  • y_2019, m_9, d_18, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201407, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.