Bromocriptine mesylate is the mesylate salt of Bromocriptine, an ergoline-derived selective agonist of D2DR and D3DR (D2 and D3 dopamine receptors). Bromocriptine demonstrated a ten-fold higher affinity at D2 over D3 in recombinant dopamine receptors. When Bromocriptine is combined with the D1-selective dopamine receptor agonist SKF38393, normalization of hyperphagia and resultant reductions of body weight and fat, serum glucose, free fatty acid and triglyceride concentrations is reported in agonist-administered ob/ob mice. Bromocriptine mesylate is an inhibitor of NOS1.
1. Perachon, S., et al. 1999. Eur. J. Pharmacol. 366: 293-300. PMID: 10082211 2. Scislowski, P.W., et al. 1999. Int. J. Obes. Relat. Metab. Disord. 23: 425-431. PMID: 10340822 3. Zhang, Y., et al. 1999. Metab. Clin. Exp. 48: 1033-1040. PMID: 10459570 4. Holt, R.I., et al. 2010. Diabetes Obes Metab. 12: 1048-1057. PMID: 20977575
Soluble in DMSO (50 mg/ml), ethanol (23 mg/ml), methanol, water (0.8 mg/ml), and chloroform:methanol(1:1).
Store at -20° C
α20/D +95°, c = 1 in methanol: dichloromethane (1:1)(lit.)
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RojasRojas-Hernandez et al. (PubMed ID 26319370) found that bromocriptine mesylate led to dopaminergic activation which resulted in enhanced sexual motivation in male rats. -SCBT Publication Review
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