Bromocriptine mesylateA selective D2 and D3 dopamine receptor agonist and NOS1 inhibitor

Bromocriptine mesylate (CAS 22260-51-1)

Bromocriptine mesylate | CAS 22260-51-1 is rated 5.0 out of 5 by 1.
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Synonym: Parlodel; Cycloset
Application: A selective D2 and D3 dopamine receptor agonist and NOS1 inhibitor
CAS Number: 22260-51-1
Purity: ≥98%
Molecular Weight: 750.70
Molecular Formula: C32H40BrN5O5•CH3SO3H
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bromocriptine mesylate is the mesylate salt of Bromocriptine, an ergoline-derived selective agonist of D2DR and D3DR (D2 and D3 dopamine receptors). Bromocriptine demonstrated a ten-fold higher affinity at D2 over D3 in recombinant dopamine receptors. When Bromocriptine is combined with the D1-selective dopamine receptor agonist SKF38393, normalization of hyperphagia and resultant reductions of body weight and fat, serum glucose, free fatty acid and triglyceride concentrations is reported in agonist-administered ob/ob mice. Bromocriptine mesylate is an inhibitor of NOS1.


References

1. Perachon, S., et al. 1999. Eur. J. Pharmacol. 366: 293-300. PMID: 10082211
2. Scislowski, P.W., et al. 1999. Int. J. Obes. Relat. Metab. Disord. 23: 425-431. PMID: 10340822
3. Zhang, Y., et al. 1999. Metab. Clin. Exp. 48: 1033-1040. PMID: 10459570
4. Holt, R.I., et al. 2010. Diabetes Obes Metab. 12: 1048-1057. PMID: 20977575

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), ethanol (23 mg/ml), methanol, water (0.8 mg/ml), and chloroform:methanol(1:1).
Storage :
Store at -20° C
Optical Activity :
α20/D +95°, c = 1 in methanol: dichloromethane (1:1)(lit.)
IC50 :
nNOS: IC50 = 10 µM; iNOS: IC50 >100 µM; Mg2+ ATPase: IC50 = 300 nM
Ki Data :
Verapamil-induced P-glycoprotein ATPase: Ki= 200 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KE1595000
PubChem CID :
31100
Merck Index :
14: 1416
MDL Number :
MFCD00069218
EC Number :
244-881-1
Beilstein Registry :
4115238
SMILES :
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O.CS(=O)(=O)O

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Certificate of Analysis

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Bromocriptine mesylate  Product Citations

See how others have used Bromocriptine mesylate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27488872  Huang, J. et al. 2016. Cancer Res Treat.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Rojas Rojas-Hernandez et al. (PubMed ID 26319370) found that bromocriptine mesylate led to dopaminergic activation which resulted in enhanced sexual motivation in male rats. -SCBT Publication Review
Date published: 2015-06-13
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