Borrelidin (CAS 7184-60-3)

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Alternate Names: Quinquangulin K 031; Quinquangulin K 182; oxacyclooctadeca-4, 6-dien-2-yl)-

Application: Borrelidin is an anti-angiogenic and anti-microbial compound

CAS Number: 7184-60-3

Purity: 98%

Molecular Weight: 489.64

Molecular Formula: C₂₈H₄₃NO₆

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Borrelidin is derived from Streptomyces rochei and has anti-angiogenic and anti-microbial activity. The compound has been shown to inhibit both eukaryal and bacterial threonyl-tRNA synthetase (ThrRS). It also stimulate apoptosis of tube-forming cells in capillary tubes with the activation of caspase-3 and caspase-8. Research shows that Borreldin also disrupts formed capillary tubes and inhibits proliferation of human umbilical vein endothelial cell (HUVEC) proliferation. Borrelidin is an inhibitor of Cdk.

References

1. Wakabayashi, T., et al. 1997. J. Antibiot. 50: 671-677. PMID: 9315080
2. Kawamura, T. , et al. 2003. J. Antibiot. 56: 709. PMID: 14563161
3. Ruan, B., et al. 2005. J. Biol. Chem. 280: 571-577. PMID: 15507440

Physical State :

Solid

Solubility :

Soluble in ethanol, methanol (1 mg/ml), DMSO (1 mg/ml), DMF, and ethyl acetate.

Storage :

Store at -20° C

Boiling Point :

710.30° C at 760 mmHg (Predicted)

Density :

1.15 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.54 (Predicted)

IC50 :

Cyclin-dependent kinase Cdc28/Cln2: IC₅₀ = 24 µM; Antiangiogenic activity: IC₅₀ = 0.8 nM; HUVEC₅₀ (Umbilical vein endothelial cells): IC₅₀ = 0.5 nM (human); Antiproliferative activity against NCI60 cell line: IC₅₀ = 20 nM

pK Values :

pK_a: 4.56 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

ED8750000

PubChem CID :

23724539

MDL Number :

MFCD01740784

SMILES :

C[[email protected]]1C[[email protected]](C[[email protected]@H]([[email protected]](/C(=C\\C=C\\C[[email protected]@H](OC(=O)C[[email protected]@H]([[email protected]](C1)C)O)[[email protected]@H]2CCC[[email protected]]2C(=O)O)/C#N)O)C)C

Download SDS (MSDS)

Certificate of Analysis

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