Borrelidin is derived from Streptomyces rochei and has anti-angiogenic and anti-microbial activity. The compound has been shown to inhibit both eukaryal and bacterial threonyl-tRNA synthetase (ThrRS). It also stimulate apoptosis of tube-forming cells in capillary tubes with the activation of caspase-3 and caspase-8. Research shows that Borreldin also disrupts formed capillary tubes and inhibits proliferation of human umbilical vein endothelial cell (HUVEC) proliferation. Borrelidin is an inhibitor of Cdk.
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See how others have used Borrelidin (CAS 7184-60-3). Click on the entry to view the PubMed entry .
PMID: 28379541 | Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells. | Aslani, F. et al. 2017. Mol. Hum. Reprod. 23: 370-380.