Borrelidin is derived from Streptomyces rochei and has anti-angiogenic and anti-microbial activity. The compound has been shown to inhibit both eukaryal and bacterial threonyl-tRNA synthetase (ThrRS). It also stimulate apoptosis of tube-forming cells in capillary tubes with the activation of caspase-3 and caspase-8. Research shows that Borreldin also disrupts formed capillary tubes and inhibits proliferation of human umbilical vein endothelial cell (HUVEC) proliferation. Borrelidin is an inhibitor of Cdk.
1. Wakabayashi, T., et al. 1997. J. Antibiot. 50: 671-677. PMID: 9315080 2. Kawamura, T. , et al. 2003. J. Antibiot. 56: 709. PMID: 14563161 3. Ruan, B., et al. 2005. J. Biol. Chem. 280: 571-577. PMID: 15507440
Soluble in ethanol, methanol (1 mg/ml), DMSO (1 mg/ml), DMF, and ethyl acetate.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Mirando AC; et alMirando AC; et al. (PubMed ID: 26271225) determined that Borrelidin's mechansim of action is linked to its competition with the threonine substrate, which increases amino acid starvation and apoptosis. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.