Borrelidin is derived from Streptomyces rochei and has anti-angiogenic and anti-microbial activity. The compound has been shown to inhibit both eukaryal and bacterial threonyl-tRNA synthetase (ThrRS). It also stimulate apoptosis of tube-forming cells in capillary tubes with the activation of caspase-3 and caspase-8. Research shows that Borreldin also disrupts formed capillary tubes and inhibits proliferation of human umbilical vein endothelial cell (HUVEC) proliferation. Borrelidin is an inhibitor of Cdk.
1. Wakabayashi, T., et al. 1997. J. Antibiot. 50: 671-677. PMID: 9315080 2. Kawamura, T. , et al. 2003. J. Antibiot. 56: 709. PMID: 14563161 3. Ruan, B., et al. 2005. J. Biol. Chem. 280: 571-577. PMID: 15507440
Soluble in ethanol, methanol (1 mg/ml), DMSO (1 mg/ml), DMF, and ethyl acetate.
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Mirando AC; et alMirando AC; et al. (PubMed ID: 26271225) determined that Borrelidin's mechansim of action is linked to its competition with the threonine substrate, which increases amino acid starvation and apoptosis. -SCBT Publication Review
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