Borrelidin CAS: 7184-60-3
MF: C28H43NO6
MW: 489.64
An anti-angiogenic and anti-microbial compound.

Borrelidin (CAS 7184-60-3)

Borrelidin | CAS 7184-60-3 is rated 5.0 out of 5 by 1.
  • y_2020, m_8, d_11, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200379, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 131ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: Quinquangulin K 031; Quinquangulin K 182; oxacyclooctadeca-4, 6-dien-2-yl)-
Application: Borrelidin is an anti-angiogenic and anti-microbial compound
CAS Number: 7184-60-3
Purity: 98%
Molecular Weight: 489.64
Molecular Formula: C28H43NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Borrelidin is derived from Streptomyces rochei and has anti-angiogenic and anti-microbial activity. The compound has been shown to inhibit both eukaryal and bacterial threonyl-tRNA synthetase (ThrRS). It also stimulate apoptosis of tube-forming cells in capillary tubes with the activation of caspase-3 and caspase-8. Research shows that Borreldin also disrupts formed capillary tubes and inhibits proliferation of human umbilical vein endothelial cell (HUVEC) proliferation. Borrelidin is an inhibitor of Cdk.


References

1. Wakabayashi, T., et al. 1997. J. Antibiot. 50: 671-677. PMID: 9315080
2. Kawamura, T. , et al. 2003. J. Antibiot. 56: 709. PMID: 14563161
3. Ruan, B., et al. 2005. J. Biol. Chem. 280: 571-577. PMID: 15507440

Physical State :
Solid
Solubility :
Soluble in ethanol, methanol (1 mg/ml), DMSO (1 mg/ml), DMF, and ethyl acetate.
Storage :
Store at -20° C
Boiling Point :
710.30° C at 760 mmHg (Predicted)
Density :
1.15 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
Cyclin-dependent kinase Cdc28/Cln2: IC50 = 24 µM; Antiangiogenic activity: IC50 = 0.8 nM; HUVEC50 (Umbilical vein endothelial cells): IC50 = 0.5 nM (human); Antiproliferative activity against NCI60 cell line: IC50 = 20 nM
pK Values :
pKa: 4.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ED8750000
PubChem CID :
23724539
MDL Number :
MFCD01740784

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Borrelidin (CAS 7184-60-3)  Product Citations

See how others have used Borrelidin (CAS 7184-60-3). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28379541  Aslani, F. et al. 2017. Mol. Hum. Reprod. 23: 370-380.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 94ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Mirando AC; et al Mirando AC; et al. (PubMed ID: 26271225) determined that Borrelidin's mechansim of action is linked to its competition with the threonine substrate, which increases amino acid starvation and apoptosis. -SCBT Publication Review
Date published: 2015-05-05
  • y_2020, m_8, d_11, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200379, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 19ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.