Boc-Lys(Tfa)-AMCA fluorogenic substrate for the assaying of histone deacetylase 4, 5, 7

Boc-Lys(Tfa)-AMC (CAS 97885-44-4)

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Application: A fluorogenic substrate for the assaying of histone deacetylase 4, 5, 7
CAS Number: 97885-44-4
Purity: ≥98%
Molecular Weight: 499.49
Molecular Formula: C23H28F3N3O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Boc-Lys(Tfa)-AMC is a fluorogenic substrate for the assaying of histone deacetylase (HDAC) 4, 5 and 7 activity in a protease-coupled assay. It is also a suitable substrate for HDAC 8. The deacylated product Boc-Lys-AMC corresponds to I-1880.


References

1. Riester, D., et al. 2004. Biochem. Biophys. Res. Commun. 324: 1116-1123. PMID: 15485670
2. Lahm, A., et al., Proc. Natl. Acad. Sci. U.S.A. 104: 17335-17340. PMID: 17956988

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
291.42° C (Predicted)
Boiling Point :
~694.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
pK Values :
pKa: 11.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10323670
MDL Number :
MFCD11975034
SMILES :
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)OC(C)(C)C

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Certificate of Analysis

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