Date published: 2025-12-6

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Boc-Aib-OH (CAS 30992-29-1)

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Alternate Names:
2-(Boc-amino)isobutyric Acid
CAS Number:
30992-29-1
Molecular Weight:
203.24
Molecular Formula:
C9H17NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Boc-Aib-OH is a compound that functions as a protecting group in peptide synthesis. It is used to temporarily block specific functional groups within a peptide molecule, allowing for selective reactions to occur at other sites. Boc-Aib-Oh acts by forming a covalent bond with the target functional group, effectively masking it from unwanted reactions during the synthesis process. Boc-Aib-OH′s mechanism of action involves reversible protection of the amine group, preventing undesired side reactions and ensuring the desired chemical transformations occur at the intended sites. Boc-Aib-Oh plays a role in peptide chemistry by enabling the stepwise assembly of complex peptide sequences with high precision and selectivity. Its function as a protecting group allows for the efficient and controlled synthesis of peptides with specific sequences and structures, contributing to the advancement of research in the field of peptide-based materials and bioactive compounds.


Boc-Aib-OH (CAS 30992-29-1) References

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  2. Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.  |  Brunel, FM., et al. 2006. J Virol. 80: 1680-7. PMID: 16439525
  3. Multiple conformational states in crystals and in solution in alphagamma hybrid peptides. Fragility of the C12 helix in short sequences.  |  Chatterjee, S., et al. 2008. J Org Chem. 73: 6595-606. PMID: 18662036
  4. Ligand-accelerated cross-coupling of C(sp2)-H bonds with arylboron reagents.  |  Engle, KM., et al. 2011. J Am Chem Soc. 133: 18183-93. PMID: 21913636
  5. Unraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires.  |  Horsley, JR., et al. 2014. J Am Chem Soc. 136: 12479-88. PMID: 25122122
  6. Ribbon structure stabilized by C10 and C12 turns in αγ hybrid peptide.  |  Wani, NA., et al. 2016. J Pept Sci. 22: 208-13. PMID: 27028205
  7. An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate.  |  Jo, M., et al. 2018. Arch Pharm Res. 41: 259-264. PMID: 29478110
  8. Synthesis of Functionalized Cyclopropanes from Carboxylic Acids by a Radical Addition-Polar Cyclization Cascade.  |  Shu, C., et al. 2018. Angew Chem Int Ed Engl. 57: 15430-15434. PMID: 30204292
  9. α,ε-Hybrid Peptide Foldamers: Self-Assembly of Peptide with Trans Carbon-Carbon Double Bonds in the Backbone and Its Saturated Analogue.  |  Debnath, M., et al. 2018. ACS Omega. 3: 8760-8768. PMID: 31459008
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  12. Effects of end group and aggregation on helix conformation: crystal structure of Ac-(Aib-Val-Ala-Leu)2-Aib-OMe.  |  Karle, IL., et al. 1996. J Pept Sci. 2: 106-16. PMID: 9225250
  13. Potent 3-spiropiperidine growth hormone secretagogues.  |  Yang, L., et al. 1998. Bioorg Med Chem Lett. 8: 107-12. PMID: 9925440

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Boc-Aib-OH, 5 g

sc-254989
5 g
$36.00