BMY 7378 dihydrochlorideCAS: 21102-95-4
MF: C22H31N3O3•2HCl
MW: 458.42
A SR-1A agonist and a selective α1D-AR antagonist.

BMY 7378 dihydrochloride (CAS 21102-95-4)

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Synonym: N-(2-(4-(o-Methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimide dihydrochloride
Application: A SR-1A agonist and a selective α1D-AR antagonist
CAS Number: 21102-95-4
Molecular Weight: 458.42
Molecular Formula: C22H31N3O32HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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BMY 7378 dihydrochloride is a putative SR-1A (5-HT1A) partial agonist, and high affinity α1D-AR adrenoceptor antagonist.


References

1. Sharp, T., et al. 1990. Eur. J. Pharmacol. 176: 331-340. PMID: 1970304
2. Piascik, M.D., et al. 1995. J. Pharmacol. Exp. Ther. 275: 1583-1589. PMID: 8531132
3. Yang, H.T. and Endoh, M. 1997. Br. J. Pharmacol. 122: 1541-1550. PMID: 9422797

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml), DMSO (92 mg/ml), and ethanol (20 mg/ml).
Storage :
Store at 4° C
Melting Point :
196.5-198.5° C
Boiling Point :
585.6° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Ki Data :
α1B adrenoceptor : Ki= 0.6 µM (hamster); α1D adrenoceptor : Ki= 2.8 µM (rat); α1A adrenoceptor : Ki= 2.8 µM (rat)
pK Values :
pKb: 7.15 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GY3996000
PubChem CID :
210172
MDL Number :
MFCD00153771
SMILES :
COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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