BMS-790052A hepatitis C virus (HCV) NS5A inhibitor

BMS-790052 (CAS 1214735-16-6)

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Synonym: Daclatasvir
Application: A hepatitis C virus (HCV) NS5A inhibitor
CAS Number: 1214735-16-6
Molecular Weight: 738.88
Molecular Formula: C40H50N8O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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BMS-790052 is a first-in-class, highly selective inhibitor of hepatitis C virus (HCV) NS5A with an EC50 of 9–50 pM. BMS-790052 is one of the most potent inhibitors of HCV replication reported so far. The mean EC50 values of BMS-790052 are 50 and 9pM for HCV genotype 1a and 1b replicons, respectively. BMS-790052 displays a therapeutic index (CC50/EC50) of at least 105 and is inactive towards a panel of 10 RNA and DNA viruses, with EC50 higher than 10μM. This confirms BMS-790052's specificity for HCV. In Huh7 cells harboring the HCV genotype 1b replicons, BMS-790052 blocks both transient and stable HCV genome replication, with EC50 values raging from 1–15 pM. BMS-790052 (100 pM or 1 nM) has been shown to alter the subcellular localization and biochemical fractionation of NS5A. BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with EC50 of 7–13 pM. Residue 30 of NS5A is an important site for BMS-790052-mediated resistance in the hybrid replicons.

Physical State :
Solid
Solubility :
≥148 mg/mL in DMSO <1 mg/mL in Water ≥148 mg/mL in Ethanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25154714
SMILES :
CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC

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Certificate of Analysis

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